Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F17%3A00000040" target="_blank" >RIV/46747885:24410/17:00000040 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pat.3875" target="_blank" >10.1002/pat.3875</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Popis výsledku v původním jazyce

Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of mate-rials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with innerdiameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(L-lactide)caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types ineach layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechani-cally. Obtained results of mechanical performance were discussed according to the used polymer-type composition,fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaf-folds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable poly-mers in different combinations in each layer causes notable differences in fiber morphology and mechanicalperformance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pres-sures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracel-lular matrix of tunica media in native vessels.

Název v anglickém jazyce

Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Popis výsledku anglicky

Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of mate-rials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with innerdiameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(L-lactide)caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types ineach layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechani-cally. Obtained results of mechanical performance were discussed according to the used polymer-type composition,fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaf-folds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable poly-mers in different combinations in each layer causes notable differences in fiber morphology and mechanicalperformance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pres-sures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracel-lular matrix of tunica media in native vessels.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/NV15-29241A" target="_blank" >NV15-29241A: Nanovlákenná biodegradabilní maloprůměrová cévní náhrada</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymers for Advanced Technologies

ISSN

1042-7147

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

201-213

Kód UT WoS článku

000393706200008

EID výsledku v databázi Scopus

2-s2.0-84989232435