Design of Polycaprolactone Vascular Grafts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F14%3A%230003928" target="_blank" >RIV/46747885:24410/14:#0003928 - isvavai.cz</a>

Výsledek na webu

<a href="http://jit.sagepub.com/content/early/2014/06/23/1528083714540701.full.pdf+html" target="_blank" >http://jit.sagepub.com/content/early/2014/06/23/1528083714540701.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1528083714540701" target="_blank" >10.1177/1528083714540701</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Design of Polycaprolactone Vascular Grafts

Popis výsledku v původním jazyce

A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6?mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector.The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2??m average fiber diameter provide 1?MPa ultimate tensile strength in the radial direction. The pore size area was found tobe adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a

Název v anglickém jazyce

Design of Polycaprolactone Vascular Grafts

Popis výsledku anglicky

A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6?mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector.The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2??m average fiber diameter provide 1?MPa ultimate tensile strength in the radial direction. The pore size area was found tobe adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/ED3.1.00%2F14.0306" target="_blank" >ED3.1.00/14.0306: Inovativní výrobky a environmentální technologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Industrial Textiles

ISSN

1530-8057

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

June

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

21

Strana od-do

1-21

Kód UT WoS článku

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EID výsledku v databázi Scopus

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