Design of Polycaprolactone Vascular Grafts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00008797" target="_blank" >RIV/46747885:24410/16:00008797 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.sagepub.com/doi/pdf/10.1177/1528083714540701" target="_blank" >http://journals.sagepub.com/doi/pdf/10.1177/1528083714540701</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1528083714540701" target="_blank" >10.1177/1528083714540701</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Design of Polycaprolactone Vascular Grafts

Popis výsledku v původním jazyce

A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector. The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2 µm average fiber diameter provide 1 MPa ultimate tensile strength in the radial direction. The pore size area was found to be adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a cue for radial cell alignment. An understanding of electrospun material parameters together with knowledge of native blood vessel structures and properties is a considerable part in designing small-diameter vascular grafts.

Název v anglickém jazyce

Design of Polycaprolactone Vascular Grafts

Popis výsledku anglicky

A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector. The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2 µm average fiber diameter provide 1 MPa ultimate tensile strength in the radial direction. The pore size area was found to be adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a cue for radial cell alignment. An understanding of electrospun material parameters together with knowledge of native blood vessel structures and properties is a considerable part in designing small-diameter vascular grafts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20503 - Textiles; including synthetic dyes, colours, fibres (nanoscale materials to be 2.10; biomaterials to be 2.9)

Projekt

<a href="/cs/project/GAP208%2F12%2F0105" target="_blank" >GAP208/12/0105: ROZTOKY POLYMERŮ VE VNĚJŠÍM POLI: MOLEKULÁRNÍ POCHOPENÍ ELEKTROSPINNINGU</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Industrial Textiles

ISSN

1528-0837

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

21

Strana od-do

813-833

Kód UT WoS článku

000372174900012

EID výsledku v databázi Scopus

2-s2.0-84962610841