Fibrous Three Dimensional Scaffolds for Creation of Organoids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00000868" target="_blank" >RIV/46747885:24410/16:00000868 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fibrous Three Dimensional Scaffolds for Creation of Organoids

Popis výsledku v původním jazyce

Hydra XII Summer School on Stem Cell Biology, 11-18 September 2016, Edinburgh and Cambridge University, Hydra, GreeceOral and poster presentationAbstractThis study describes the production, testing and characterization of biodegradable cellular 3D scaffolds for tissue engineering, which are consisting of a mixture of microfibers produced by meltblowing and nanofibers produced by electrospinning. All the samples are produced from polycaprolactone. The prepared materials showed the optimal porosity for the inner cell proliferation and compared with a purely nanofibrous materials have good mechanical properties. Useful structural properties and homogenity of the material are described by electron microscopy and image analysis. These carriers are easy to saturate by the hydrogels and functionalized with biomolecules. Was characterized the biocompatibility and cells proliferation by in - vitro testing of the different ratio of microfibers and nanofibers and the different pores size. Subsequent in - vivo testing on selected biological models confirmed a solid materials ability to create required tissue for bone regeneration or for new organids creating.

Název v anglickém jazyce

Fibrous Three Dimensional Scaffolds for Creation of Organoids

Popis výsledku anglicky

Hydra XII Summer School on Stem Cell Biology, 11-18 September 2016, Edinburgh and Cambridge University, Hydra, GreeceOral and poster presentationAbstractThis study describes the production, testing and characterization of biodegradable cellular 3D scaffolds for tissue engineering, which are consisting of a mixture of microfibers produced by meltblowing and nanofibers produced by electrospinning. All the samples are produced from polycaprolactone. The prepared materials showed the optimal porosity for the inner cell proliferation and compared with a purely nanofibrous materials have good mechanical properties. Useful structural properties and homogenity of the material are described by electron microscopy and image analysis. These carriers are easy to saturate by the hydrogels and functionalized with biomolecules. Was characterized the biocompatibility and cells proliferation by in - vitro testing of the different ratio of microfibers and nanofibers and the different pores size. Subsequent in - vivo testing on selected biological models confirmed a solid materials ability to create required tissue for bone regeneration or for new organids creating.

Druh

O - Ostatní výsledky

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

<a href="/cs/project/ED3.1.00%2F14.0308" target="_blank" >ED3.1.00/14.0308: Nanovlákenné materiály pro tkáňové inženýrství</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů