Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47122099%3A_____%2F18%3AN0000005" target="_blank" >RIV/47122099:_____/18:N0000005 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00213-018-4899-3" target="_blank" >https://link.springer.com/article/10.1007/s00213-018-4899-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-018-4899-3" target="_blank" >10.1007/s00213-018-4899-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Popis výsledku v původním jazyce

Rationale: There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer’s disease and other dementias) usable for preclinical research. Objectives: We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. Methods: We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention; (2) delayed matching to position (DMP), to evaluate working memory; and (3) “counter-balanced acquisition,” to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. Results: A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. Conclusions: Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.

Název v anglickém jazyce

Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Popis výsledku anglicky

Rationale: There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer’s disease and other dementias) usable for preclinical research. Objectives: We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. Methods: We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention; (2) delayed matching to position (DMP), to evaluate working memory; and (3) “counter-balanced acquisition,” to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. Results: A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. Conclusions: Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

1432-2072

e-ISSN

0033-3158

Svazek periodika

235

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

213-225

Kód UT WoS článku

000436110900015

EID výsledku v databázi Scopus

2-s2.0-85045729041