Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00491286" target="_blank" >RIV/67985823:_____/18:00491286 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00213-018-4899-3" target="_blank" >http://dx.doi.org/10.1007/s00213-018-4899-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-018-4899-3" target="_blank" >10.1007/s00213-018-4899-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Popis výsledku v původním jazyce

There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer's disease and other dementias) usable for preclinical research. We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention, (2) delayed matching to position (DMP), to evaluate working memory, and (3) “counter-balanced acquisition” to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.

Název v anglickém jazyce

Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat

Popis výsledku anglicky

There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer's disease and other dementias) usable for preclinical research. We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention, (2) delayed matching to position (DMP), to evaluate working memory, and (3) “counter-balanced acquisition” to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA17-04047S" target="_blank" >GA17-04047S: Dysfunkce atraktorových sítí u schizofrenie a obsedantně kompulzivní poruchy: Translační testy hypotézy dynamických systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

0033-3158

e-ISSN

—

Svazek periodika

235

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

2013-2025

Kód UT WoS článku

000436110900015

EID výsledku v databázi Scopus

2-s2.0-85045729041