Morphology of the Immune Cells in the Wall of the Human Uterine Tube and Their Possible Impact on Reproduction - Uterine Tube as a Possible Immune Privileged Organ

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23310%2F24%3A43971564" target="_blank" >RIV/49777513:23310/24:43971564 - isvavai.cz</a>

Výsledek na webu

<a href="http://doi.org/10.3389/fcell.2024.1325565" target="_blank" >http://doi.org/10.3389/fcell.2024.1325565</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcell.2024.1325565" target="_blank" >10.3389/fcell.2024.1325565</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Morphology of the Immune Cells in the Wall of the Human Uterine Tube and Their Possible Impact on Reproduction - Uterine Tube as a Possible Immune Privileged Organ

Popis výsledku v původním jazyce

The uterine tube, as well as other parts of the upper female reproductive system, is immunologically unique in its requirements for tolerance to allogenic sperm and semi-allogenic embryos, yet responds to an array of sexually transmitted pathogens. To understand this dichotomy, there is a need to understand the functional morphology of immune cells in the wall of the uterine tube. Thus, we reviewed scientific literature regarding immune cells and the human uterine tube by using the scientific databases. The human uterine tube has a diverse population of immunocompetent cells representing both the innate and adaptive immune systems. We describe in detail the possible roles of cells of the mononuclear phagocyte system (macrophages and dendritic cells), T and B lymphocytes, NK cells, neutrophils and mast cells in association with the reproductive functions of uterine tubes. We are also discussing about the possible &quot;immune privilege&quot; of the uterine tube, as another mechanism to tolerate sperm and embryo without eliciting an inflammatory immune response. In uterine tube is not present an anatomical blood-tissue barrier between antigens and circulation. However, the immune cells of the uterine tube probably represent a type of &quot;immunological barrier&quot;, which probably includes the uterine tube among the immunologically privileged organs. Understanding how immune cells in the female reproductive tract play roles in reproduction is essential to understand not only the mechanisms of gamete transport and fertilization as well as embryo transport through the uterine tube, but also in improving results from assisted reproduction.

Název v anglickém jazyce

Morphology of the Immune Cells in the Wall of the Human Uterine Tube and Their Possible Impact on Reproduction - Uterine Tube as a Possible Immune Privileged Organ

Popis výsledku anglicky

The uterine tube, as well as other parts of the upper female reproductive system, is immunologically unique in its requirements for tolerance to allogenic sperm and semi-allogenic embryos, yet responds to an array of sexually transmitted pathogens. To understand this dichotomy, there is a need to understand the functional morphology of immune cells in the wall of the uterine tube. Thus, we reviewed scientific literature regarding immune cells and the human uterine tube by using the scientific databases. The human uterine tube has a diverse population of immunocompetent cells representing both the innate and adaptive immune systems. We describe in detail the possible roles of cells of the mononuclear phagocyte system (macrophages and dendritic cells), T and B lymphocytes, NK cells, neutrophils and mast cells in association with the reproductive functions of uterine tubes. We are also discussing about the possible &quot;immune privilege&quot; of the uterine tube, as another mechanism to tolerate sperm and embryo without eliciting an inflammatory immune response. In uterine tube is not present an anatomical blood-tissue barrier between antigens and circulation. However, the immune cells of the uterine tube probably represent a type of &quot;immunological barrier&quot;, which probably includes the uterine tube among the immunologically privileged organs. Understanding how immune cells in the female reproductive tract play roles in reproduction is essential to understand not only the mechanisms of gamete transport and fertilization as well as embryo transport through the uterine tube, but also in improving results from assisted reproduction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Cell and Developmental Biology

ISSN

2296-634X

e-ISSN

2296-634X

Svazek periodika

12

Číslo periodika v rámci svazku

7 March 2024

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

001189521500001

EID výsledku v databázi Scopus

2-s2.0-85188170935