Enhanced frequency of micronuclei in lymphocytes from current as opposed to former uranium miners

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F11%3A43881875" target="_blank" >RIV/60076658:12110/11:43881875 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2478/v10136-011-0002-7" target="_blank" >http://dx.doi.org/10.2478/v10136-011-0002-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-011-0002-7" target="_blank" >10.2478/v10136-011-0002-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhanced frequency of micronuclei in lymphocytes from current as opposed to former uranium miners

Popis výsledku v původním jazyce

Micronuclei can be used as markers of past radiation exposure, but few studies have dealt with alpha radiation. Here we report on micronuclei in lymphocytes from uranium miners currently working at Rožná, Czech Republic, the last functioning uranium minein the European Union. A modified micronucleus-centromere test was applied, assessing the occurrence of micronuclei in stimulated lymphocytes as well as their content in terms of whole chromosomes or fragments. Compared with unexposed individuals, the miners had higher frequencies of micronucleus-containing lymphocytes and higher percentages of micronuclei without centromeres, and the differences were significant with both parameters (0.74 + 0.60 vs. 0.50 + 0.42, p=0.017 and 49 + 44 vs. 12 + 21, p=0.0002; means + standard deviations). There were also significant correlations between either of these parameters on the one hand and various dose values on the other, in particular with "retrievable" dose, i.e. a dose the effect of which sho

Název v anglickém jazyce

Enhanced frequency of micronuclei in lymphocytes from current as opposed to former uranium miners

Popis výsledku anglicky

Micronuclei can be used as markers of past radiation exposure, but few studies have dealt with alpha radiation. Here we report on micronuclei in lymphocytes from uranium miners currently working at Rožná, Czech Republic, the last functioning uranium minein the European Union. A modified micronucleus-centromere test was applied, assessing the occurrence of micronuclei in stimulated lymphocytes as well as their content in terms of whole chromosomes or fragments. Compared with unexposed individuals, the miners had higher frequencies of micronucleus-containing lymphocytes and higher percentages of micronuclei without centromeres, and the differences were significant with both parameters (0.74 + 0.60 vs. 0.50 + 0.42, p=0.017 and 49 + 44 vs. 12 + 21, p=0.0002; means + standard deviations). There were also significant correlations between either of these parameters on the one hand and various dose values on the other, in particular with "retrievable" dose, i.e. a dose the effect of which sho

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/2B08001" target="_blank" >2B08001: Biologická dozimetrie pro osoby profesně vystavené ionizujícímu záření alfa</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

151-156

Kód UT WoS článku

000291678000004

EID výsledku v databázi Scopus

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