Micronuclei in lymphocytes from currently active uranium miners

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F12%3A00202019" target="_blank" >RIV/68407700:21460/12:00202019 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12110/12:43884462 RIV/00216208:11120/12:43909542

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00411-012-0422-0" target="_blank" >http://link.springer.com/article/10.1007%2Fs00411-012-0422-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00411-012-0422-0" target="_blank" >10.1007/s00411-012-0422-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Micronuclei in lymphocytes from currently active uranium miners

Popis výsledku v původním jazyce

Micronuclei can be used as markers of past radiation exposure, but only few studies have dealt with uranium miners. In this paper, we report on micronuclei in lymphocytes from individuals currently working at Rožná, Czech Republic, the last functioning uranium mine in the European Union. A modified micronucleus-centromere test was applied to assess the occurrence of micronuclei in stimulated lymphocytes, as well as their content in terms of whole chromosomes or fragments. Compared with unexposed individuals, the miners had higher frequencies of micronucleus-containing lymphocytes and higher percentages of micronuclei without centromeres, and the differences were significant for both parameters (0.74 ? 0.60 vs. 0.50 ? 0.42, p = 0.017 and 49 ? 44 vs. 12? 21, p = 0.0002; means ? standard deviations). There were also significant correlations between one or other of these parameters on the one hand and various dose values on the other, in particular with a 'retrievable' dose, that is, a do

Název v anglickém jazyce

Micronuclei in lymphocytes from currently active uranium miners

Popis výsledku anglicky

Micronuclei can be used as markers of past radiation exposure, but only few studies have dealt with uranium miners. In this paper, we report on micronuclei in lymphocytes from individuals currently working at Rožná, Czech Republic, the last functioning uranium mine in the European Union. A modified micronucleus-centromere test was applied to assess the occurrence of micronuclei in stimulated lymphocytes, as well as their content in terms of whole chromosomes or fragments. Compared with unexposed individuals, the miners had higher frequencies of micronucleus-containing lymphocytes and higher percentages of micronuclei without centromeres, and the differences were significant for both parameters (0.74 ? 0.60 vs. 0.50 ? 0.42, p = 0.017 and 49 ? 44 vs. 12? 21, p = 0.0002; means ? standard deviations). There were also significant correlations between one or other of these parameters on the one hand and various dose values on the other, in particular with a 'retrievable' dose, that is, a do

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/2B08001" target="_blank" >2B08001: Biologická dozimetrie pro osoby profesně vystavené ionizujícímu záření alfa</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation and Environmental Biophysics

ISSN

0301-634X

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

277-282

Kód UT WoS článku

000306694000005

EID výsledku v databázi Scopus

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