Micronucleus frequency and content in healthy relatives of cancer patients.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F17%3A43896095" target="_blank" >RIV/60076658:12110/17:43896095 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/17:00482212

Výsledek na webu

<a href="http://dx.doi.org/10.1080/1354750X.2016.1276627" target="_blank" >http://dx.doi.org/10.1080/1354750X.2016.1276627</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1354750X.2016.1276627" target="_blank" >10.1080/1354750X.2016.1276627</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Micronucleus frequency and content in healthy relatives of cancer patients.

Popis výsledku v původním jazyce

OBJECTIVE: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer. MATERIALS AND METHODS: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei. RESULTS: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n.s.) and the proportion of centromere-free micronuclei (p &lt; 0.05) in some subgroups, but not in all. CONCLUSION: The chromosomal damage observed may be due to inheritable genomic instability, but environmental influences cannot be excluded.

Název v anglickém jazyce

Micronucleus frequency and content in healthy relatives of cancer patients.

Popis výsledku anglicky

OBJECTIVE: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer. MATERIALS AND METHODS: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei. RESULTS: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n.s.) and the proportion of centromere-free micronuclei (p &lt; 0.05) in some subgroups, but not in all. CONCLUSION: The chromosomal damage observed may be due to inheritable genomic instability, but environmental influences cannot be excluded.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomarkers

ISSN

1354-750X

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

667-673

Kód UT WoS článku

000413979200011

EID výsledku v databázi Scopus

2-s2.0-85010002333