Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883405" target="_blank" >RIV/60076658:12520/12:43883405 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aquatox.2012.06.009" target="_blank" >http://dx.doi.org/10.1016/j.aquatox.2012.06.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2012.06.009" target="_blank" >10.1016/j.aquatox.2012.06.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish

Popis výsledku v původním jazyce

In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand VZ adverse effects on male reproduction, mature goldfish (Carassius auratus) were exposed to three nominal VZ concentrations (100, 400, and 800 mu g/L) and alternations in gonadosomatic (GSI) and hepatosomatic indices (HSI), 17 beta-estradiol (E-2), 11-ketotestosterone (11-KT) and sperm quality were investigated compared to the solvent control. One group was exposed to E-2 (nominal concentration of 5 mu g/L), an estrogenic compound, as a negative control. Following one month exposure, GSI and HSIwere unchanged in all VZ treated groups compared to solvent control. Sperm volume, motility and velocity were reduced in fish exposed to 800 mu g/L VZ. This was associated with the decrease in 11-KT level, suggesting direct VZ effects on

Název v anglickém jazyce

Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish

Popis výsledku anglicky

In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand VZ adverse effects on male reproduction, mature goldfish (Carassius auratus) were exposed to three nominal VZ concentrations (100, 400, and 800 mu g/L) and alternations in gonadosomatic (GSI) and hepatosomatic indices (HSI), 17 beta-estradiol (E-2), 11-ketotestosterone (11-KT) and sperm quality were investigated compared to the solvent control. One group was exposed to E-2 (nominal concentration of 5 mu g/L), an estrogenic compound, as a negative control. Following one month exposure, GSI and HSIwere unchanged in all VZ treated groups compared to solvent control. Sperm volume, motility and velocity were reduced in fish exposed to 800 mu g/L VZ. This was associated with the decrease in 11-KT level, suggesting direct VZ effects on

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aquatic Toxicology

ISSN

0166-445X

e-ISSN

—

Svazek periodika

122

Číslo periodika v rámci svazku

08

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

181-187

Kód UT WoS článku

000308972000021

EID výsledku v databázi Scopus

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