Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A64302" target="_blank" >RIV/60460709:41210/14:64302 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12520/14:43886843

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo

Popis výsledku v původním jazyce

The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfish were exposed to 100, 400 and 800 ?g/L VZ and 5 ?g/L 17ß-estradiol (E2) for comparison. In VZ treated goldfish, 11-ketotesteosterone (11-KT) secretion was changed depending on dose and duration period of treatment. Following 7 days of exposure, 11-KT was decreased in goldfish exposed to 800 ?g/L VZ, while it was increased in goldfish exposed to 100 ?g/L VZ after 30 days of exposure. Circulating E2 level was unchanged in VZ treated goldfish, however the E2/11-KT ratio was increased in a dose-related manner. In E2 treated goldfish, circulatory 11-KT and E2 levels were decreased and increased respectively, which resulted in an increase in the E2/11-KT ratio. Exposure to VZ at 100 ?g/L caused a significant increase in the circulatory

Název v anglickém jazyce

Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo

Popis výsledku anglicky

The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfish were exposed to 100, 400 and 800 ?g/L VZ and 5 ?g/L 17ß-estradiol (E2) for comparison. In VZ treated goldfish, 11-ketotesteosterone (11-KT) secretion was changed depending on dose and duration period of treatment. Following 7 days of exposure, 11-KT was decreased in goldfish exposed to 800 ?g/L VZ, while it was increased in goldfish exposed to 100 ?g/L VZ after 30 days of exposure. Circulating E2 level was unchanged in VZ treated goldfish, however the E2/11-KT ratio was increased in a dose-related manner. In E2 treated goldfish, circulatory 11-KT and E2 levels were decreased and increased respectively, which resulted in an increase in the E2/11-KT ratio. Exposure to VZ at 100 ?g/L caused a significant increase in the circulatory

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AQUATIC TOXICOLOGY

ISSN

0166-445X

e-ISSN

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Svazek periodika

155

Číslo periodika v rámci svazku

N

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

73-83

Kód UT WoS článku

000342245300009

EID výsledku v databázi Scopus

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