Di-(2-ethylhexyl)-phthalate disrupts pituitary and testicular hormonal functions to reduce sperm quality in mature goldfish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F15%3A43888550" target="_blank" >RIV/60076658:12520/15:43888550 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0166445X15000910" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166445X15000910</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2015.03.017" target="_blank" >10.1016/j.aquatox.2015.03.017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Di-(2-ethylhexyl)-phthalate disrupts pituitary and testicular hormonal functions to reduce sperm quality in mature goldfish

Popis výsledku v původním jazyce

Di-(2-ethylhexyl) phthalate (DEHP) interferes with male reproductive endocrine system in mammals, however its effects on fish reproduction are largely unknown. We evaluated sperm quality and investigated reproductive endocrine system in mature goldfish (Carassius auratus) exposed to nominal 1, 10, and 100 mu g/L DEHP. To examine DEHP estrogenic activity, one group of goldfish was exposed to 17 beta-estradiol (5 mu g/L E-2) for comparison. Following 30 d of exposure, sperm production was decreased and suppressed in DEHP and E-2 treated goldfish, respectively. Sperm motility and velocity were decreased in goldfish exposed to 100 and 10 mu g/L DEHP at 15s post-sperm activation, respectively. Compared to control, 11-ketotestosterone (11-KT) levels were decreased at 10 and 1 mu g/L DEHP at day 15 and 30, respectively. In E-2 treated goldfish, 11-KT levels were decreased compared to control during the period of exposure. E-2 levels were increased in goldfish exposed to E-2, but remained unch

Název v anglickém jazyce

Di-(2-ethylhexyl)-phthalate disrupts pituitary and testicular hormonal functions to reduce sperm quality in mature goldfish

Popis výsledku anglicky

Di-(2-ethylhexyl) phthalate (DEHP) interferes with male reproductive endocrine system in mammals, however its effects on fish reproduction are largely unknown. We evaluated sperm quality and investigated reproductive endocrine system in mature goldfish (Carassius auratus) exposed to nominal 1, 10, and 100 mu g/L DEHP. To examine DEHP estrogenic activity, one group of goldfish was exposed to 17 beta-estradiol (5 mu g/L E-2) for comparison. Following 30 d of exposure, sperm production was decreased and suppressed in DEHP and E-2 treated goldfish, respectively. Sperm motility and velocity were decreased in goldfish exposed to 100 and 10 mu g/L DEHP at 15s post-sperm activation, respectively. Compared to control, 11-ketotestosterone (11-KT) levels were decreased at 10 and 1 mu g/L DEHP at day 15 and 30, respectively. In E-2 treated goldfish, 11-KT levels were decreased compared to control during the period of exposure. E-2 levels were increased in goldfish exposed to E-2, but remained unch

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aquatic Toxicology

ISSN

0166-445X

e-ISSN

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Svazek periodika

163

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

16-26

Kód UT WoS článku

000355050900002

EID výsledku v databázi Scopus

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