Encapsulation and release behavior of curcumin based on nanoemulsions-filled alginate hydrogel beads

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F19%3A43899223" target="_blank" >RIV/60076658:12520/19:43899223 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0141813019317192" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813019317192</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2019.04.200" target="_blank" >10.1016/j.ijbiomac.2019.04.200</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Encapsulation and release behavior of curcumin based on nanoemulsions-filled alginate hydrogel beads

Popis výsledku v původním jazyce

To provide the bilateral advantages of emulsions and hydrogels, a facile approach was used to fabricate nanoemulsions filled hydrogel beads through combining the method of self-emulsification and sodium alginate (SA) ionic gelation. The encapsulation and release behavior of curcumin (Cur) were further investigated. The results indicated that Cur packaged nanoemulsions were with the size of 24.26 +/- 0.22 nm. The nanoemulsions filled SA hydrogel beads were spherical shell with the diameter of 0.46 +/- 0.02 mm. For Cur, the EE and LC of emulsion filled SA hydrogel beads were 99.15 +/- 0.85% and 7.25 +/- 3.16 mg/g respectively. The release behavior could be regulated by external pH condition. The release behavior at pH 9.0 displayed a higher release rate than that at pH 7.0. Cur released behavior well followed the Hixcon-Crowell model which indicated that Cur was released in a diffusion-controlled model. Comparatively investigation of microstructure using field emission scanning electron microscope (FE-SEM) further investigates the corrosion behavior of SA gel beads during Cur release. The worth-while endeavor provided a practical combined technique of emulsions and ionic gelation to fabricate hybrid hydrogel beads that have potential in delivery system for hydrophobic composition. (C) 2019 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Encapsulation and release behavior of curcumin based on nanoemulsions-filled alginate hydrogel beads

Popis výsledku anglicky

To provide the bilateral advantages of emulsions and hydrogels, a facile approach was used to fabricate nanoemulsions filled hydrogel beads through combining the method of self-emulsification and sodium alginate (SA) ionic gelation. The encapsulation and release behavior of curcumin (Cur) were further investigated. The results indicated that Cur packaged nanoemulsions were with the size of 24.26 +/- 0.22 nm. The nanoemulsions filled SA hydrogel beads were spherical shell with the diameter of 0.46 +/- 0.02 mm. For Cur, the EE and LC of emulsion filled SA hydrogel beads were 99.15 +/- 0.85% and 7.25 +/- 3.16 mg/g respectively. The release behavior could be regulated by external pH condition. The release behavior at pH 9.0 displayed a higher release rate than that at pH 7.0. Cur released behavior well followed the Hixcon-Crowell model which indicated that Cur was released in a diffusion-controlled model. Comparatively investigation of microstructure using field emission scanning electron microscope (FE-SEM) further investigates the corrosion behavior of SA gel beads during Cur release. The worth-while endeavor provided a practical combined technique of emulsions and ionic gelation to fabricate hybrid hydrogel beads that have potential in delivery system for hydrophobic composition. (C) 2019 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

—

Svazek periodika

134

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

210-215

Kód UT WoS článku

000474673600024

EID výsledku v databázi Scopus

2-s2.0-85065392576