Metabolic sensors and their interplay with cell signalling and transcription

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00384133" target="_blank" >RIV/60077344:_____/12:00384133 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/12:43883959

Výsledek na webu

<a href="http://www.biochemsoctrans.org/bst/040/0311/0400311.pdf" target="_blank" >http://www.biochemsoctrans.org/bst/040/0311/0400311.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BST20110767" target="_blank" >10.1042/BST20110767</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metabolic sensors and their interplay with cell signalling and transcription

Popis výsledku v původním jazyce

There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription.Central metabolic pathways are under the control of signalling pathways and, vice versa, cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability directly and crucially influences crucial cell decisions. In the present review, I summarize our current knowledgeof various metabolic sensors and give some examples of the integration of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate on the collection of small-molecule metabolites, whose concentration fluctuates in response to cellular energy levels, sea

Název v anglickém jazyce

Metabolic sensors and their interplay with cell signalling and transcription

Popis výsledku anglicky

There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription.Central metabolic pathways are under the control of signalling pathways and, vice versa, cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability directly and crucially influences crucial cell decisions. In the present review, I summarize our current knowledgeof various metabolic sensors and give some examples of the integration of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate on the collection of small-molecule metabolites, whose concentration fluctuates in response to cellular energy levels, sea

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP305%2F11%2F0126" target="_blank" >GAP305/11/0126: Signalizace pres Notch receptor v kontextu bunecneho metabolismu.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical Society Transactions

ISSN

0300-5127

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

311-323

Kód UT WoS článku

000303624200002

EID výsledku v databázi Scopus

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