A deep phylogeny of viral and cellular right-hand polymerases

Kód výsledku v IS VaVaI

RIV/60077344:_____/15:00450322 - isvavai.cz

Nalezeny alternativní kódy

RIV/60460709:41340/15:65008 RIV/60076658:12310/15:43890209

Výsledek na webu

http://dx.doi.org/10.1016/j.meegid.2015.09.026

DOI - Digital Object Identifier

10.1016/j.meegid.2015.09.026

Jazyk výsledku

angličtina

Název v původním jazyce

A deep phylogeny of viral and cellular right-hand polymerases

Popis výsledku v původním jazyce

Right-hand polymerases are important players in genome replication and repair in cellular organisms as well as in viruses. All right-hand polymerases are grouped into seven related protein families: viral RNA-dependent RNA polymerases, reverse transcriptases, single-subunit RNA polymerases, and DNA polymerase families A, B, D, and Y. Although the evolutionary relationships of right-hand polymerases within each family have been proposed, evolutionary relationships between families remain elusive becausetheir sequence similarity is too low to allow classical phylogenetic analyses. The structure of viral RNA-dependent RNA polymerases recently was shown to be useful in inferring their evolution. Here, we address evolutionary relationships between righthand polymerase families by combining sequence and structure information.We used a set of 22 viral and cellular polymerases representing all right-hand polymerase families with known protein structure. In contrast to previous studies, which

Název v anglickém jazyce

A deep phylogeny of viral and cellular right-hand polymerases

Popis výsledku anglicky

Right-hand polymerases are important players in genome replication and repair in cellular organisms as well as in viruses. All right-hand polymerases are grouped into seven related protein families: viral RNA-dependent RNA polymerases, reverse transcriptases, single-subunit RNA polymerases, and DNA polymerase families A, B, D, and Y. Although the evolutionary relationships of right-hand polymerases within each family have been proposed, evolutionary relationships between families remain elusive becausetheir sequence similarity is too low to allow classical phylogenetic analyses. The structure of viral RNA-dependent RNA polymerases recently was shown to be useful in inferring their evolution. Here, we address evolutionary relationships between righthand polymerase families by combining sequence and structure information.We used a set of 22 viral and cellular polymerases representing all right-hand polymerase families with known protein structure. In contrast to previous studies, which

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection, Genetics and Evolution

ISSN

1567-1348

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

2015-Dec

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

275-286

Kód UT WoS článku

000367548300036

EID výsledku v databázi Scopus

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