Detection of tick-borne encephalits virus RNA in patient samples across different infection stages

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00599755" target="_blank" >RIV/60077344:_____/24:00599755 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/48" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/48</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Detection of tick-borne encephalits virus RNA in patient samples across different infection stages

Popis výsledku v původním jazyce

Tick-borne encephalitis (TBE) is an important neuroviral disease in Europe and Asia, characterised by abiphasic progression: an initial viremic phase with nonspecific symptoms, followed by a neurological phase1. This study evaluated the effectiveness of detecting TBE virus (TBEV) RNA in various clinical samples from 1,125 patients in South Bohemia, Czech Republic, a highly endemic region for TBE. The samples included blood, serum, cerebrospinal fluid (CSF), and urine. The detection of TBEV RNA was most successful in serum during early infection but decreased as the IgG antibody response developed. Rarely, RNA was detectable in serum even after seroconversion.

Název v anglickém jazyce

Detection of tick-borne encephalits virus RNA in patient samples across different infection stages

Popis výsledku anglicky

Tick-borne encephalitis (TBE) is an important neuroviral disease in Europe and Asia, characterised by abiphasic progression: an initial viremic phase with nonspecific symptoms, followed by a neurological phase1. This study evaluated the effectiveness of detecting TBE virus (TBEV) RNA in various clinical samples from 1,125 patients in South Bohemia, Czech Republic, a highly endemic region for TBE. The samples included blood, serum, cerebrospinal fluid (CSF), and urine. The detection of TBEV RNA was most successful in serum during early infection but decreased as the IgG antibody response developed. Rarely, RNA was detectable in serum even after seroconversion.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů