Antibacterial Activity and Chemical Composition of Popular Plant Essential Oils and Their Positive Interactions in Combination

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00635511" target="_blank" >RIV/60077344:_____/25:00635511 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027006:_____/25:10178078

Výsledek na webu

<a href="https://www.mdpi.com/1420-3049/30/9/1864/pdf?version=1745724076" target="_blank" >https://www.mdpi.com/1420-3049/30/9/1864/pdf?version=1745724076</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules30091864" target="_blank" >10.3390/molecules30091864</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antibacterial Activity and Chemical Composition of Popular Plant Essential Oils and Their Positive Interactions in Combination

Popis výsledku v původním jazyce

Bacterial diseases are a global problem that threatens human health and cause many deaths each year. The alarming rise in bacterial resistance to modern antimicrobials is particularly concerning. In practice, this necessitates increasing the dosage of antimicrobial agents, posing a potential risk of adverse effects on human health. Additionally, the development of antibiotic resistance is one of the main factors contributing to the ever-growing costs of the global healthcare system. For these reasons, natural and safe antimicrobial agents are increasingly sought after. In this study, the antibacterial activity of 31 different essential oils (EOs) was investigated against Escherichia coli and Staphylococcus aureus. The most effective EOs were further tested both individually and in dual combinations. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs) were determined to reveal synergistic effects, suggesting potential practical applications. The main bioactive compounds of the EOs with the highest inhibitory activity were identified and quantified using GC-MS/MS analysis. Of the tested EOs, seven demonstrated a strong antimicrobial effect against E. coli, most notably oregano (MIC 128 mu g/mL) and the thyme/oregano combination (MIC 64 mu g/mL, FIC 0.75), while thirteen were effective against S. aureus, most notably oregano and garlic (MIC 128 mu g/mL),and the pelargonium/garlic combination (MIC 32 mu g/mL, FIC 0.375). The pharmaceutical, agricultural, and food industries are promising fields for the application of these safe and natural antimicrobial agents, offering a new range of solutions to combat serious bacterial pathogens.

Název v anglickém jazyce

Antibacterial Activity and Chemical Composition of Popular Plant Essential Oils and Their Positive Interactions in Combination

Popis výsledku anglicky

Bacterial diseases are a global problem that threatens human health and cause many deaths each year. The alarming rise in bacterial resistance to modern antimicrobials is particularly concerning. In practice, this necessitates increasing the dosage of antimicrobial agents, posing a potential risk of adverse effects on human health. Additionally, the development of antibiotic resistance is one of the main factors contributing to the ever-growing costs of the global healthcare system. For these reasons, natural and safe antimicrobial agents are increasingly sought after. In this study, the antibacterial activity of 31 different essential oils (EOs) was investigated against Escherichia coli and Staphylococcus aureus. The most effective EOs were further tested both individually and in dual combinations. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs) were determined to reveal synergistic effects, suggesting potential practical applications. The main bioactive compounds of the EOs with the highest inhibitory activity were identified and quantified using GC-MS/MS analysis. Of the tested EOs, seven demonstrated a strong antimicrobial effect against E. coli, most notably oregano (MIC 128 mu g/mL) and the thyme/oregano combination (MIC 64 mu g/mL, FIC 0.75), while thirteen were effective against S. aureus, most notably oregano and garlic (MIC 128 mu g/mL),and the pelargonium/garlic combination (MIC 32 mu g/mL, FIC 0.375). The pharmaceutical, agricultural, and food industries are promising fields for the application of these safe and natural antimicrobial agents, offering a new range of solutions to combat serious bacterial pathogens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

1420-3049

Svazek periodika

30

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

1864

Kód UT WoS článku

001486457900001

EID výsledku v databázi Scopus

2-s2.0-105004862229