The relationship between structure and in vitro antistaphylococcal effect of plant-derived stilbenes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A78208" target="_blank" >RIV/60460709:41210/18:78208 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/18:00499672 RIV/60460709:41340/18:78208

Výsledek na webu

<a href="http://dx.doi.org/10.1556/030.65.2018.040" target="_blank" >http://dx.doi.org/10.1556/030.65.2018.040</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1556/030.65.2018.040" target="_blank" >10.1556/030.65.2018.040</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The relationship between structure and in vitro antistaphylococcal effect of plant-derived stilbenes

Popis výsledku v původním jazyce

Staphylococcus aureus is a major human pathogen that is responsible for both hospital and community acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth inhibitory potential of eight naturally occurring stilbenes against six standard strains and two clinical isolates of S. aureus, using a broth microdilution method, and expressing the results as minimum inhibitory concentrations (MICs). Pterostilbene (MICs from 32 to 128 mu g per ml), piceatannol (MICs from 64 to 256 mu g per ml), and pinostilbene (MICs 128 mu g per ml) are among the active compounds that possess the strongest activity against all microorganisms tested, followed by 3 hydroxypterostilbene, isorhapontigenin, oxyresveratrol, and rhapontigenin with MICs from 128 to 256 mu g per ml. Resveratrol (MIC 256 mu g per ml) exhibited only weak inhibitory effect. Furthermore,

Název v anglickém jazyce

The relationship between structure and in vitro antistaphylococcal effect of plant-derived stilbenes

Popis výsledku anglicky

Staphylococcus aureus is a major human pathogen that is responsible for both hospital and community acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth inhibitory potential of eight naturally occurring stilbenes against six standard strains and two clinical isolates of S. aureus, using a broth microdilution method, and expressing the results as minimum inhibitory concentrations (MICs). Pterostilbene (MICs from 32 to 128 mu g per ml), piceatannol (MICs from 64 to 256 mu g per ml), and pinostilbene (MICs 128 mu g per ml) are among the active compounds that possess the strongest activity against all microorganisms tested, followed by 3 hydroxypterostilbene, isorhapontigenin, oxyresveratrol, and rhapontigenin with MICs from 128 to 256 mu g per ml. Resveratrol (MIC 256 mu g per ml) exhibited only weak inhibitory effect. Furthermore,

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21101 - Food and beverages

Projekt

<a href="/cs/project/GA16-07193S" target="_blank" >GA16-07193S: Protizánětlivá aktivita vybraných stilbenů, 2-arylbenzofuranů a jejich metabolitů</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA

ISSN

1217-8950

e-ISSN

1588-2640

Svazek periodika

65

Číslo periodika v rámci svazku

December 2018

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

467-476

Kód UT WoS článku

000453790600005

EID výsledku v databázi Scopus

2-s2.0-85058702011