Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F26%3A00650870" target="_blank" >RIV/60077344:_____/26:00650870 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/26:00650870

Výsledek na webu

<a href="https://doi.org/10.1038/s41467-026-69475-0" target="_blank" >https://doi.org/10.1038/s41467-026-69475-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-026-69475-0" target="_blank" >10.1038/s41467-026-69475-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress

Popis výsledku v původním jazyce

Diet is one of the strongest ecological forces shaping the gut environment, yet its impact on intestinal worms (helminths) remains poorly understood. The helminth Hymenolepis diminuta is a suitable model for investigating how lifestyle changes in modern societies may disrupt host-helminth relationships. Here we show that dietary fiber availability shapes the developmental trajectory and life strategies of H. diminuta in a stage-dependent manner. Fiber deprivation at the time of host colonization leads to developmental arrest, manifested by reduced growth, absence of reproduction, and transcriptional changes consistent with suppressed development. This state is accompanied by diet-dependent remodeling of the host small intestinal microbiota and metabolome: whereas fiber-rich diets support fermentative microbial communities and a chemically diverse intestinal environment, the Western diet promotes dysbiotic profiles with reduced fermentation capacity and a more pro-inflammatory immune response. In contrast, adult H. diminuta that reach maturity in hosts maintained on a fiber-rich diet exhibit a reversible, estivation-like suppression of reproduction during short-term fiber deprivation, with full restoration of egg production following dietary recovery. Together, these findings indicate that dietary transitions associated with industrialized lifestyles can redirect helminth developmental programs and host-helminth-microbiome interactions, with implications for helminth persistence and potential therapeutic applications.

Název v anglickém jazyce

Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress

Popis výsledku anglicky

Diet is one of the strongest ecological forces shaping the gut environment, yet its impact on intestinal worms (helminths) remains poorly understood. The helminth Hymenolepis diminuta is a suitable model for investigating how lifestyle changes in modern societies may disrupt host-helminth relationships. Here we show that dietary fiber availability shapes the developmental trajectory and life strategies of H. diminuta in a stage-dependent manner. Fiber deprivation at the time of host colonization leads to developmental arrest, manifested by reduced growth, absence of reproduction, and transcriptional changes consistent with suppressed development. This state is accompanied by diet-dependent remodeling of the host small intestinal microbiota and metabolome: whereas fiber-rich diets support fermentative microbial communities and a chemically diverse intestinal environment, the Western diet promotes dysbiotic profiles with reduced fermentation capacity and a more pro-inflammatory immune response. In contrast, adult H. diminuta that reach maturity in hosts maintained on a fiber-rich diet exhibit a reversible, estivation-like suppression of reproduction during short-term fiber deprivation, with full restoration of egg production following dietary recovery. Together, these findings indicate that dietary transitions associated with industrialized lifestyles can redirect helminth developmental programs and host-helminth-microbiome interactions, with implications for helminth persistence and potential therapeutic applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

2041-1723

Svazek periodika

17

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

2985

Kód UT WoS článku

001729876000003

EID výsledku v databázi Scopus

2-s2.0-105034757621