In vitro schopnost H oximů (HI-6, Hlo-7), oximu BI-6 a v současnosti užívaných oximů (pralidoxim, obidoxim, trimedoxim) reaktivovat acetylcholinesterázu inhibovanou NPL

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001493" target="_blank" >RIV/60162694:G44__/06:00001493 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase

Popis výsledku v původním jazyce

The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested by in vitro methods. Both H oximes (HI-6,HLö-7) as well as the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and doesnot reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of them can be considered to be a broad spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of their high potency to reactivate acetylcholinesterase inhibited by some nerve agents. Therefore, more than one oxime should be introduced for the antidotal treatment of nerve agent-exposed people.

Název v anglickém jazyce

In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase

Popis výsledku anglicky

The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6 and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested by in vitro methods. Both H oximes (HI-6,HLö-7) as well as the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and doesnot reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of them can be considered to be a broad spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of their high potency to reactivate acetylcholinesterase inhibited by some nerve agents. Therefore, more than one oxime should be introduced for the antidotal treatment of nerve agent-exposed people.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Toxicology and Environmental Health

ISSN

0098-4108

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1431-1440

Kód UT WoS článku

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EID výsledku v databázi Scopus

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