Strukturní faktory ovlivňující schopnost v současnosti užívaných reaktivátorů AChE léčit cyklosarinové intoxikace

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001809" target="_blank" >RIV/60162694:G44__/07:00001809 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications

Popis výsledku v původním jazyce

Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the

Název v anglickém jazyce

Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications

Popis výsledku anglicky

Cyclosarin is one member of nerve agents´ family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Vztah mezi strukturou reaktivátorů acetylcholinesterázy a jejich reaktivační účinností</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Pharmaceutical Design

ISSN

1381-6128

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

33

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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