Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874790" target="_blank" >RIV/60162694:G44__/13:43874790 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.stmconnect.com/sites/default/files/41-43%20%20JEIT-D-12-00014.pdf" target="_blank" >http://www.stmconnect.com/sites/default/files/41-43%20%20JEIT-D-12-00014.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7178/jeit.16" target="_blank" >10.7178/jeit.16</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents

Popis výsledku v původním jazyce

Cholinesterase reactivators are a group of drugs originally developed as antidotes for treatment of nerve agent intoxications. Although there are five commercially available members of this group, none is considered to be a universal solution for treatment of intoxication caused by all nerve agents. Due to this, novel drug candidates are searched. To find the most promising antidotes, structure activity studies are conducted. In this contribution, distance between quaternary nitrogen and aldoxime (called oxime) group responsible for the reactivation process is discussed. For this purpose, three structurally different oxime reactivators were tested for their potency to reactivate tabun, sarin, cyclosarin and VX agent-inhibited acetylcholinesterase (AC hE; EC 3.1.1.7). As resulted, only "standard" oxime reactivators with oxime group connected to the heteroaromatic ring could be considered as promising AC hE reactivators. Those with oxime group on other aromatic ring or those with quatern

Název v anglickém jazyce

Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents

Popis výsledku anglicky

Cholinesterase reactivators are a group of drugs originally developed as antidotes for treatment of nerve agent intoxications. Although there are five commercially available members of this group, none is considered to be a universal solution for treatment of intoxication caused by all nerve agents. Due to this, novel drug candidates are searched. To find the most promising antidotes, structure activity studies are conducted. In this contribution, distance between quaternary nitrogen and aldoxime (called oxime) group responsible for the reactivation process is discussed. For this purpose, three structurally different oxime reactivators were tested for their potency to reactivate tabun, sarin, cyclosarin and VX agent-inhibited acetylcholinesterase (AC hE; EC 3.1.1.7). As resulted, only "standard" oxime reactivators with oxime group connected to the heteroaromatic ring could be considered as promising AC hE reactivators. Those with oxime group on other aromatic ring or those with quatern

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT12062" target="_blank" >NT12062: Příprava a hodnocení účinnosti nových terapeutik proti otravám pesticidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Environmental Immunology and Toxicology

ISSN

2225-1219

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

41-43

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—