Charakterizace imunitní odpovědi potkanů linie Lewis na inokulaci buněk sarkomové linie K2 a na nově odvozené maligní buňky R5-28

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F05%3A14122" target="_blank" >RIV/60460709:41210/05:14122 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/05:00027346 RIV/00216208:11310/05:9299

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 Malignant Cells

Popis výsledku v původním jazyce

Sarcoma is a relatively rare malignant disease with high mortality, bad prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22th25th day after inoculation (D = 2225), only 60%75% of R5-28-inoculated rats were affected by tumours. Thefrequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in both cases. All affected animals showed large splenomegaly. Apossible response of some immune system components to tumours was tested. No tumourinfiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers of

Název v anglickém jazyce

Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 Malignant Cells

Popis výsledku anglicky

Sarcoma is a relatively rare malignant disease with high mortality, bad prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22th25th day after inoculation (D = 2225), only 60%75% of R5-28-inoculated rats were affected by tumours. Thefrequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in both cases. All affected animals showed large splenomegaly. Apossible response of some immune system components to tumours was tested. No tumourinfiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GG - Chov hospodářských zvířat

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F04%2F0102" target="_blank" >GA524/04/0102: Studium imunologické odpovědi po devitalizaci nádorů u různých živočišných modelů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica - Prague

ISSN

0015-5500

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

159-165

Kód UT WoS článku

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EID výsledku v databázi Scopus

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