Imunologická charakteristika potkanů kmene Lewis osídlených K2 sarkomovou buněčnou linií a nově vytvořenými R5-28 maligními buňkami

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F06%3A16358" target="_blank" >RIV/60460709:41210/06:16358 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Imunologická charakteristika potkanů kmene Lewis osídlených K2 sarkomovou buněčnou linií a nově vytvořenými R5-28 maligními buňkami

Popis výsledku v původním jazyce

Sarcoma is a relatively rare malignant disease with high mortality, but prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22nd 25th day after inoculation (D = 22-25), only 60%-75% of R5-28-inoculated rats were affected by tumours.The frequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in all cases. All affected animals showed large splenomegaly. A possible response of some immune system components to tumours was tested. Notumour infiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers

Název v anglickém jazyce

Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 malignant cells

Popis výsledku anglicky

Sarcoma is a relatively rare malignant disease with high mortality, but prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22nd 25th day after inoculation (D = 22-25), only 60%-75% of R5-28-inoculated rats were affected by tumours.The frequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in all cases. All affected animals showed large splenomegaly. A possible response of some immune system components to tumours was tested. Notumour infiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GG - Chov hospodářských zvířat

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica - Prague

ISSN

0015-5500

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

51

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

159-165

Kód UT WoS článku

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EID výsledku v databázi Scopus

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