Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp infantis in vitro and in humanised mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A73599" target="_blank" >RIV/60460709:41210/17:73599 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/17:00475173

Výsledek na webu

<a href="http://dx.doi.org/10.3920/BM2016.0138" target="_blank" >http://dx.doi.org/10.3920/BM2016.0138</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3920/BM2016.0138" target="_blank" >10.3920/BM2016.0138</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp infantis in vitro and in humanised mice

Popis výsledku v původním jazyce

The mode of delivery plays a crucial role in infant gastrointestinal tract colonisation, which in the case of caesarean section is characterised by the presence of clostridia and low bifidobacterial counts. Gut colonisation can be modified by probiotics, prebiotics or synbiotics. Human milk oligosaccharides HMOs are infant prebiotics that show a bifidogenic effect. Moreover, genome sequencing of Bifidobacterium longum subsp. infantis within the infant microbiome revealed adaptations for milk utilisation. This study aimed to evaluate the synbiotic effect of B. longum subsp. infantis, HMOs and human milk HM both in vitro and in vivo in a humanised mouse model in the presence of faecal microbiota from infants born by caesarean section. The combination of B. longum and HMOs or HM reduced the clostridia and G bacteria counts both in vitro and in vivo. The bifidobacterial population in vitro significantly increased and produce high concentrations of acetate and lactate. In vitro competition assays confirme

Název v anglickém jazyce

Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp infantis in vitro and in humanised mice

Popis výsledku anglicky

The mode of delivery plays a crucial role in infant gastrointestinal tract colonisation, which in the case of caesarean section is characterised by the presence of clostridia and low bifidobacterial counts. Gut colonisation can be modified by probiotics, prebiotics or synbiotics. Human milk oligosaccharides HMOs are infant prebiotics that show a bifidogenic effect. Moreover, genome sequencing of Bifidobacterium longum subsp. infantis within the infant microbiome revealed adaptations for milk utilisation. This study aimed to evaluate the synbiotic effect of B. longum subsp. infantis, HMOs and human milk HM both in vitro and in vivo in a humanised mouse model in the presence of faecal microbiota from infants born by caesarean section. The combination of B. longum and HMOs or HM reduced the clostridia and G bacteria counts both in vitro and in vivo. The bifidobacterial population in vitro significantly increased and produce high concentrations of acetate and lactate. In vitro competition assays confirme

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/GA15-07268S" target="_blank" >GA15-07268S: Střevní mikrobiota a neuroendokrinní regulace během stresu</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Beneficial Microbes

ISSN

1876-2883

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

281-289

Kód UT WoS článku

000400167600013

EID výsledku v databázi Scopus

2-s2.0-85018245854