Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from Cassia fistula L. Leaves
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A83895" target="_blank" >RIV/60460709:41210/20:83895 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.mdpi.com/2076-3921/9/2/173" target="_blank" >https://www.mdpi.com/2076-3921/9/2/173</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/antiox9020173" target="_blank" >10.3390/antiox9020173</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from Cassia fistula L. Leaves
Popis výsledku v původním jazyce
Cassia fistula L. is a highly admirable traditional medicinal plant used for the treatment of various diseases and disorders. The present study was performed to divulge the antioxidant, antiproliferative, and apoptosis-inducing efficacy of fractions from C. fistula leaves. The hexane -CaLH fraction-, chloroform -CaLC fraction-, ethyl acetate -CaLE fraction-, n-butanol -CaLB fraction-, and aqueous -CaLA fraction- were sequentially fractionated from 80% methanolic -CaLM extract- of C. fistula leaves. The CaLE fraction was fractionated using column chromatography to yield a pure compound, which was characterized as Epiafzelechin -CFL1- based on H-1, C-13, and DEPT135 NMR. Among these fractions, CaLE and isolated CFL1 fractions exhibited an effective antioxidant potential in Ferric ion reducing power, -2,2-azino-bis -3-ethylbenzothiazoline -6-sulfonic acid-- cation radical scavenging, and nitric oxide radical scavenging assays. Epiafzelechin was investigated for its antiproliferative effects against MG-6
Název v anglickém jazyce
Antioxidant, Antiproliferative and Apoptosis-Inducing Efficacy of Fractions from Cassia fistula L. Leaves
Popis výsledku anglicky
Cassia fistula L. is a highly admirable traditional medicinal plant used for the treatment of various diseases and disorders. The present study was performed to divulge the antioxidant, antiproliferative, and apoptosis-inducing efficacy of fractions from C. fistula leaves. The hexane -CaLH fraction-, chloroform -CaLC fraction-, ethyl acetate -CaLE fraction-, n-butanol -CaLB fraction-, and aqueous -CaLA fraction- were sequentially fractionated from 80% methanolic -CaLM extract- of C. fistula leaves. The CaLE fraction was fractionated using column chromatography to yield a pure compound, which was characterized as Epiafzelechin -CFL1- based on H-1, C-13, and DEPT135 NMR. Among these fractions, CaLE and isolated CFL1 fractions exhibited an effective antioxidant potential in Ferric ion reducing power, -2,2-azino-bis -3-ethylbenzothiazoline -6-sulfonic acid-- cation radical scavenging, and nitric oxide radical scavenging assays. Epiafzelechin was investigated for its antiproliferative effects against MG-6
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10611 - Plant sciences, botany
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Antioxidants
ISSN
2076-3921
e-ISSN
2076-3921
Svazek periodika
9
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
16
Strana od-do
1-16
Kód UT WoS článku
000519877100099
EID výsledku v databázi Scopus
2-s2.0-85079873474