Effect of different prebiotic saccharides on Listeria monocytogenes adherence to human adenocarcinoma Caco-2 cell line

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A102296" target="_blank" >RIV/60460709:41210/25:102296 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3390/cimb47110891" target="_blank" >https://doi.org/10.3390/cimb47110891</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cimb47110891" target="_blank" >10.3390/cimb47110891</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of different prebiotic saccharides on Listeria monocytogenes adherence to human adenocarcinoma Caco-2 cell line

Popis výsledku v původním jazyce

Listeria monocytogenes (LM) is one of the most emerging pathogens responsible for the serious foodborne disease listeriosis. The risk of disease outbreaks can be reduced by suppressing the adherence of LM to the intestinal epithelial cells. This effect can be achieved by prebiotic supplementation. The aim of this work was to determine the effect of prebiotics beta-(1,3)-D-glucan, inulin, fructooligosaccharides, galactooligosaccharides, lactulose, raffinose, stachyose, human milk oligosaccharides (HMOs), and 2’-fucosyllactose on the ability of LM to adhere to the human adenocarcinoma Caco-2 cell line. Despite strain-specific variability, a statistically significant reduction in LM adhesion to intestinal epithelial cells was observed in the presence of beta-(1,3)-D-glucan (~60% reduction), inulin (~46%), and HMOs (~44%). In contrast, the remaining tested prebiotics did not show a significant impact on LM adhesion. These findings highlight the potential of specific prebiotics, especially beta-glucans, to limit LM adherence, suggesting a protective effect for the host.

Název v anglickém jazyce

Effect of different prebiotic saccharides on Listeria monocytogenes adherence to human adenocarcinoma Caco-2 cell line

Popis výsledku anglicky

Listeria monocytogenes (LM) is one of the most emerging pathogens responsible for the serious foodborne disease listeriosis. The risk of disease outbreaks can be reduced by suppressing the adherence of LM to the intestinal epithelial cells. This effect can be achieved by prebiotic supplementation. The aim of this work was to determine the effect of prebiotics beta-(1,3)-D-glucan, inulin, fructooligosaccharides, galactooligosaccharides, lactulose, raffinose, stachyose, human milk oligosaccharides (HMOs), and 2’-fucosyllactose on the ability of LM to adhere to the human adenocarcinoma Caco-2 cell line. Despite strain-specific variability, a statistically significant reduction in LM adhesion to intestinal epithelial cells was observed in the presence of beta-(1,3)-D-glucan (~60% reduction), inulin (~46%), and HMOs (~44%). In contrast, the remaining tested prebiotics did not show a significant impact on LM adhesion. These findings highlight the potential of specific prebiotics, especially beta-glucans, to limit LM adherence, suggesting a protective effect for the host.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

—

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CURRENT ISSUES IN MOLECULAR BIOLOGY

ISSN

1467-3037

e-ISSN

1467-3045

Svazek periodika

47

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

16

Strana od-do

1-16

Kód UT WoS článku

001625544800001

EID výsledku v databázi Scopus

2-s2.0-105022910876