Adheze fibroblastů na PE modifikovaném iontovým svazkem

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F04%3A00011744" target="_blank" >RIV/60461373:22310/04:00011744 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fibroblasts adhesion on ion beam modified PE

Popis výsledku v původním jazyce

Polyethylene (PE) was irradiated with 15 keV O+, P+ and Ar+ ions to the .uences from 3 x 1012 to 1 x 1015 cm-2. Thechanges of surface structure and polarity and oxygen concentration were examined on pristine and as-irradiated PE.The in vitro adhesion ofrat 3T3 fibroblasts on the modified PE was evaluated 24 h after inoculation. Degradation of PEis manifested by the creation of conjugated double bonds and oxidation of the PE main chain. It was proved that theimplanted P atoms are chemically bound onto degraded polymer chain. Wettability of the polymer surface is a.ected bythe structure and composition of the modi.ed surface layer. In comparison with pristine PE (i) higher cell adhesion isobserved on implanted PE and (ii) the cells cultivated on implanted PE are larger and their adherence is signi.cantlymore homogeneous. The enhancement of 3T3 cells adhesion is highest and smallest for PE implanted with O+ and Ar+ions, respectively. Highest cell adhesion was observed on PE implanted to

Název v anglickém jazyce

Fibroblasts adhesion on ion beam modified PE

Popis výsledku anglicky

Polyethylene (PE) was irradiated with 15 keV O+, P+ and Ar+ ions to the .uences from 3 x 1012 to 1 x 1015 cm-2. Thechanges of surface structure and polarity and oxygen concentration were examined on pristine and as-irradiated PE.The in vitro adhesion ofrat 3T3 fibroblasts on the modified PE was evaluated 24 h after inoculation. Degradation of PEis manifested by the creation of conjugated double bonds and oxidation of the PE main chain. It was proved that theimplanted P atoms are chemically bound onto degraded polymer chain. Wettability of the polymer surface is a.ected bythe structure and composition of the modi.ed surface layer. In comparison with pristine PE (i) higher cell adhesion isobserved on implanted PE and (ii) the cells cultivated on implanted PE are larger and their adherence is signi.cantlymore homogeneous. The enhancement of 3T3 cells adhesion is highest and smallest for PE implanted with O+ and Ar+ions, respectively. Highest cell adhesion was observed on PE implanted to

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA106%2F03%2F0514" target="_blank" >GA106/03/0514: Modifikované polymery pro tkáňové inženýrství</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nuclear Instruments and Methods in Physics Research, Section B

ISSN

0168-583X

e-ISSN

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Svazek periodika

neuvedeno

Číslo periodika v rámci svazku

215

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

366-372

Kód UT WoS článku

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EID výsledku v databázi Scopus

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