Adhese fibroblastů na polyethylenu modifikovaném iontovou implatací

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F04%3A00101872" target="_blank" >RIV/61389005:_____/04:00101872 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fibroblasts adhesion on ion beam modified

Popis výsledku v původním jazyce

Polyethylene (PE) was irradiated with 15 keV O+, P+ and Ar+ ions to the fluences from 3 x 10(12) to 1 X 10(15) cm(-2). The changes of surface structure and polarity and oxygen concentration were examined on pristine and as-irradiated PE. The in vitro adhesion of rat 3T3 fibroblasts on the modified PE was evaluated 24 h after inoculation. Degradation of PE is manifested by the creation of conjugated double bonds and oxidation of the PE main chain. It was proved that the implanted P atoms are chemically bound onto degraded polymer chain. Wettability of the polymer surface is affected by the structure and composition of the modified surface layer. In comparison with pristine PE (i) higher cell adhesion is observed on implanted PE and (ii) the cells cultivated on implanted PE are larger and their adherence is significantly more homogeneous. The enhancement of 3T3 cells adhesion is highest and smallest for PE implanted with O+ and Ar+ ions, respectively. Highest cell adhesion was observe...

Název v anglickém jazyce

Fibroblasts adhesion on ion beam modified

Popis výsledku anglicky

Polyethylene (PE) was irradiated with 15 keV O+, P+ and Ar+ ions to the fluences from 3 x 10(12) to 1 X 10(15) cm(-2). The changes of surface structure and polarity and oxygen concentration were examined on pristine and as-irradiated PE. The in vitro adhesion of rat 3T3 fibroblasts on the modified PE was evaluated 24 h after inoculation. Degradation of PE is manifested by the creation of conjugated double bonds and oxidation of the PE main chain. It was proved that the implanted P atoms are chemically bound onto degraded polymer chain. Wettability of the polymer surface is affected by the structure and composition of the modified surface layer. In comparison with pristine PE (i) higher cell adhesion is observed on implanted PE and (ii) the cells cultivated on implanted PE are larger and their adherence is significantly more homogeneous. The enhancement of 3T3 cells adhesion is highest and smallest for PE implanted with O+ and Ar+ ions, respectively. Highest cell adhesion was observe...

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BG - Jaderná, atomová a molekulová fyzika, urychlovače

OECD FORD obor

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Projekt

<a href="/cs/project/GA106%2F03%2F0514" target="_blank" >GA106/03/0514: Modifikované polymery pro tkáňové inženýrství</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH

ISSN

0168-583X

e-ISSN

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Svazek periodika

215

Číslo periodika v rámci svazku

3/4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

366-372

Kód UT WoS článku

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EID výsledku v databázi Scopus

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