Plasma treated polyethylene grafted with adhesive Molecules for enhanced adhesion and growth of fibroblasts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43895365" target="_blank" >RIV/60461373:22310/13:43895365 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/13:43895365

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0928493112005607" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0928493112005607</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2012.12.003" target="_blank" >10.1016/j.msec.2012.12.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma treated polyethylene grafted with adhesive Molecules for enhanced adhesion and growth of fibroblasts

Popis výsledku v původním jazyce

The cell material interface plays a crucial role in the interaction of cells with synthetic materials for biomedical use. The application of plasma for tailoring polymer surfaces is of abiding interest and holds a great promise in biomedicine. In this paper, we describe polyethylene (PE) surface tuning by Ar plasma irradiating and subsequent grafting of the chemically active PE surface with adhesive proteins or motives to support cell attachment. These simple modifications resulted in changed polymer surface hydrophilicity, roughness and morphology, which we thoroughly characterized. The effect of our modifications on adhesion and growth was tested in vitro using mouse embryonic fibroblasts (NIH 3T3 cell line). We demonstrate that the plasma treatmentof PE had a positive effect on the adhesion, spreading, homogeneity of distribution and moderately on proliferation activity of NIH 3T3 cells. This effect was even more pronounced on PE coated with biomolecules.

Název v anglickém jazyce

Plasma treated polyethylene grafted with adhesive Molecules for enhanced adhesion and growth of fibroblasts

Popis výsledku anglicky

The cell material interface plays a crucial role in the interaction of cells with synthetic materials for biomedical use. The application of plasma for tailoring polymer surfaces is of abiding interest and holds a great promise in biomedicine. In this paper, we describe polyethylene (PE) surface tuning by Ar plasma irradiating and subsequent grafting of the chemically active PE surface with adhesive proteins or motives to support cell attachment. These simple modifications resulted in changed polymer surface hydrophilicity, roughness and morphology, which we thoroughly characterized. The effect of our modifications on adhesion and growth was tested in vitro using mouse embryonic fibroblasts (NIH 3T3 cell line). We demonstrate that the plasma treatmentof PE had a positive effect on the adhesion, spreading, homogeneity of distribution and moderately on proliferation activity of NIH 3T3 cells. This effect was even more pronounced on PE coated with biomolecules.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials science and engineering C

ISSN

0928-4931

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

1116-1124

Kód UT WoS článku

000315751600015

EID výsledku v databázi Scopus

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