Sodium Aspirin Salts: Crystallization and Characterization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916878" target="_blank" >RIV/60461373:22310/18:43916878 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/18:43916878

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.cgd.8b00718" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.cgd.8b00718</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.cgd.8b00718" target="_blank" >10.1021/acs.cgd.8b00718</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sodium Aspirin Salts: Crystallization and Characterization

Popis výsledku v původním jazyce

Acetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several drug products are available with sodium aspirin as their active ingredient, but, until now, its crystal structure remained unknown. We have investigated the multicomponent system of sodium acetylsalicylate with the following results: an anhydrate and a dihydrate of a 1:1 salt were identified together with a hemihydrate of a 2:1 salt. Crystal structures of all forms were solved by single-crystal X-ray diffraction. The structural changes upon desolvation were studied by simultaneous thermogravimetric/differential scanning calorimetry supported by X-ray powder diffraction. The crystal structures were compared to those of all up-to-date published crystal structures of aspirin salts. Both of the hydrated sodium salts belong to the same isostructural family, while the anhydrate crystallizes with a unique packing of the acetylsalicylate anions.

Název v anglickém jazyce

Sodium Aspirin Salts: Crystallization and Characterization

Popis výsledku anglicky

Acetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several drug products are available with sodium aspirin as their active ingredient, but, until now, its crystal structure remained unknown. We have investigated the multicomponent system of sodium acetylsalicylate with the following results: an anhydrate and a dihydrate of a 1:1 salt were identified together with a hemihydrate of a 2:1 salt. Crystal structures of all forms were solved by single-crystal X-ray diffraction. The structural changes upon desolvation were studied by simultaneous thermogravimetric/differential scanning calorimetry supported by X-ray powder diffraction. The crystal structures were compared to those of all up-to-date published crystal structures of aspirin salts. Both of the hydrated sodium salts belong to the same isostructural family, while the anhydrate crystallizes with a unique packing of the acetylsalicylate anions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GA16-10035S" target="_blank" >GA16-10035S: Příprava farmaceutických kokrystalů a určování jejich krystalové struktury kombinací monokrystalové elektronové a RTG práškové difrakce</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Crystal Growth &amp; Design

ISSN

1528-7483

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

5287-5294

Kód UT WoS článku

000444218400059

EID výsledku v databázi Scopus

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