Prediction of drug-carrier compatibility - Application of inverse gas chromatography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918643" target="_blank" >RIV/60461373:22310/19:43918643 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prediction of drug-carrier compatibility - Application of inverse gas chromatography

Popis výsledku v původním jazyce

Most properties of final solid dosage forms, such as tablets, capsules or granules, are highly dependent on chosen excipients, especially on the interactions between their particles and those of active substance affecting the stability or content uniformity of the final product. Since many phenomena initiate at the particle surfaces, surface properties are one of the critical parameters known to influence formulation performance. Especially surface energy can project into several unit operations. Moreover, surface properties can be changed by these pre-treatment operations, primarily mixing or milling. The work was focused on the change in surface energy as a consequence of different mixing duration. Inverse gas chromatography was used to determine any changes in surface energy of levocetirizine dihydrochloride which was mixed with Kollidon® 12 PF or Kollidon® VA 64 in a weight ratio of 1:1. Furthermore, the energy balance of surface energy was employed to assess whether the components form agglomerates.

Název v anglickém jazyce

Prediction of drug-carrier compatibility - Application of inverse gas chromatography

Popis výsledku anglicky

Most properties of final solid dosage forms, such as tablets, capsules or granules, are highly dependent on chosen excipients, especially on the interactions between their particles and those of active substance affecting the stability or content uniformity of the final product. Since many phenomena initiate at the particle surfaces, surface properties are one of the critical parameters known to influence formulation performance. Especially surface energy can project into several unit operations. Moreover, surface properties can be changed by these pre-treatment operations, primarily mixing or milling. The work was focused on the change in surface energy as a consequence of different mixing duration. Inverse gas chromatography was used to determine any changes in surface energy of levocetirizine dihydrochloride which was mixed with Kollidon® 12 PF or Kollidon® VA 64 in a weight ratio of 1:1. Furthermore, the energy balance of surface energy was employed to assess whether the components form agglomerates.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1613" target="_blank" >LO1613: Výzkum nových materiálů pro chemický průmysl</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 7th International Conference on Chemical Technology

ISBN

978-80-88307-00-6

ISSN

2336-811X

e-ISSN

2336-8128

Počet stran výsledku

5

Strana od-do

264-268

Název nakladatele

Czech Society of Industrial Chemistry

Místo vydání

Prague

Místo konání akce

Mikulov

Datum konání akce

15. 4. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000515696600048