HIGHLY SENSITIVE MICROFLUIDIC SENSOR ARCHITECTURE FOR SERS MEASUREMENTS OF HORMONES
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43923371" target="_blank" >RIV/60461373:22310/21:43923371 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.37904/nanocon.2020.3743" target="_blank" >https://doi.org/10.37904/nanocon.2020.3743</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2020.3743" target="_blank" >10.37904/nanocon.2020.3743</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
HIGHLY SENSITIVE MICROFLUIDIC SENSOR ARCHITECTURE FOR SERS MEASUREMENTS OF HORMONES
Popis výsledku v původním jazyce
Today, there is considerable interest in the development of microfluidic chips that can be integrated into various analytical devices and further used for chemical or biological research. The microfluidic approach can reduce the size of all types of analytical laboratory equipment's and improve their technological performances. In addition, in combination with Surface Enhanced Raman Scattering (SERS), microfluidic devices can detect unprecedentedly low concentrations of targeted analytes. SERS provides a significant amplification of the nonlinear optical response of a molecule adsorbed on a suitable plasmon-active (most often silver or gold) surface (for example nanograting, nanoparticles, etc.). On the other hand, microfluidics allows a substantial reduction in the volume of sample required for analysis. In this work, an approach based on a combination of SERS and microfluidics was implemented and enables the detection of low concentrations of the target analyte - hormones. Proposed preparation of microfluidic chip comprises several subsequent steps: (i) preparation of microfluidic platform using 3D printing; (ii) laser assisted creation of patterned surface, further covered by a thin Au layer, ensuring the excitation of surface plasmon polariton in the microfluidic canal, (iii) subsequent grafting of -NH2 groups, and their activation for hormones entrapping. The rapid, reproducible, and ultrasensitive detection of hormones - Bisphenol, Estradiol, Estriol 10(-6) M) was achieved.
Název v anglickém jazyce
HIGHLY SENSITIVE MICROFLUIDIC SENSOR ARCHITECTURE FOR SERS MEASUREMENTS OF HORMONES
Popis výsledku anglicky
Today, there is considerable interest in the development of microfluidic chips that can be integrated into various analytical devices and further used for chemical or biological research. The microfluidic approach can reduce the size of all types of analytical laboratory equipment's and improve their technological performances. In addition, in combination with Surface Enhanced Raman Scattering (SERS), microfluidic devices can detect unprecedentedly low concentrations of targeted analytes. SERS provides a significant amplification of the nonlinear optical response of a molecule adsorbed on a suitable plasmon-active (most often silver or gold) surface (for example nanograting, nanoparticles, etc.). On the other hand, microfluidics allows a substantial reduction in the volume of sample required for analysis. In this work, an approach based on a combination of SERS and microfluidics was implemented and enables the detection of low concentrations of the target analyte - hormones. Proposed preparation of microfluidic chip comprises several subsequent steps: (i) preparation of microfluidic platform using 3D printing; (ii) laser assisted creation of patterned surface, further covered by a thin Au layer, ensuring the excitation of surface plasmon polariton in the microfluidic canal, (iii) subsequent grafting of -NH2 groups, and their activation for hormones entrapping. The rapid, reproducible, and ultrasensitive detection of hormones - Bisphenol, Estradiol, Estriol 10(-6) M) was achieved.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
—
OECD FORD obor
20501 - Materials engineering
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
12TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH &amp; APPLICATION (NANOCON 2020)
ISBN
978-80-87294-98-7
ISSN
—
e-ISSN
—
Počet stran výsledku
5
Strana od-do
399-403
Název nakladatele
Tanger s.r.o.
Místo vydání
Ostrava
Místo konání akce
Brno
Datum konání akce
21. 10. 2020
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
000664505500068