Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008458" target="_blank" >RIV/60461373:22330/03:00008458 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22640/03:00008458

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein

Popis výsledku v původním jazyce

The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV chan

Název v anglickém jazyce

Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein

Popis výsledku anglicky

The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV chan

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ELSO Proceedings

ISBN

0021-9524

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

281

Název nakladatele

GBM

Místo vydání

Frankfurt/Main

Místo konání akce

Drážďany

Datum konání akce

20. 9. 2003

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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