Skládání MPMV kapsid in vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012742" target="_blank" >RIV/60461373:22330/04:00012742 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Assembly of M-PMV retroviral capsids in vitro

Popis výsledku v původním jazyce

Retroviruses are subject of intensive studies not only in context with AIDS pandemia and oncogenic effect on several organisms including human. The understanding of retroviral capsid assembly mechanisms and nucleic acids incorporation could significantlycontribute to further use of these systems for therapeutic purposes. Our research is focused on study of forming of Mason-Pfizer monkey virus (M-PMV) immature capsids in vitro. M PMV as the prototype of D-type retrovirus is an excellent model for assembly studies. These retroviruses are characterized by the assembly of intracytoplasmic capsids, which make their way to the plasma membrane and are released by budding. Gag polyproteins of all retroviruses contain domains corresponding to the structural proteins which are important for driving the assembly process, namely matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.We have found specific conditions under which we can prepare properly assembled capsids in vitro from structural p

Název v anglickém jazyce

Assembly of M-PMV retroviral capsids in vitro

Popis výsledku anglicky

Retroviruses are subject of intensive studies not only in context with AIDS pandemia and oncogenic effect on several organisms including human. The understanding of retroviral capsid assembly mechanisms and nucleic acids incorporation could significantlycontribute to further use of these systems for therapeutic purposes. Our research is focused on study of forming of Mason-Pfizer monkey virus (M-PMV) immature capsids in vitro. M PMV as the prototype of D-type retrovirus is an excellent model for assembly studies. These retroviruses are characterized by the assembly of intracytoplasmic capsids, which make their way to the plasma membrane and are released by budding. Gag polyproteins of all retroviruses contain domains corresponding to the structural proteins which are important for driving the assembly process, namely matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.We have found specific conditions under which we can prepare properly assembled capsids in vitro from structural p

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A079" target="_blank" >LN00A079: Centrum integrované genomiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the XIX. meeting of czech and slovak societies for biochemistry and molecular biology

ISBN

0232-0061

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

96-97

Název nakladatele

Univerzita Palackého

Místo vydání

Olomouc

Místo konání akce

Olomouc

Datum konání akce

1. 1. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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