Vývoj enzymové imunoanalýzy pro detekci isoflavonů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012767" target="_blank" >RIV/60461373:22330/04:00012767 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of an enzyme immunoassay for the determination of isoflavones

Popis výsledku v původním jazyce

Isoflavones are plant secondary metabolites typical for leguminous plants, however they were found also in certain non-leguminous taxa. Isoflavones were reported to display a wide scale of biological effects in plant-consuming animals including humans. They are endocrinologicaly active due to interaction with estrogen receptors and due to modulation of several hormonogenic metabolic pathways. Genistein is well known inhibitor of tyrosine-protein kinases - the enzymes acting in post-receptor events of peptide hormone signaling. Dietary isoflavones have been reported protective against several types of neoplasias, cardiovascular diseaeses and menopausal symtoms. Enzyme-linked immunosorbent assays (ELISAs) were developed for determination of the most important isoflavones - i.e. genistein, daidzein and biochanin A in biological materials. The indirect competitive ELISA format uses polyclonal rabbit antibodies formed against conjugates of carboxymethyl isoflavones with bovine serum albumin

Název v anglickém jazyce

Development of an enzyme immunoassay for the determination of isoflavones

Popis výsledku anglicky

Isoflavones are plant secondary metabolites typical for leguminous plants, however they were found also in certain non-leguminous taxa. Isoflavones were reported to display a wide scale of biological effects in plant-consuming animals including humans. They are endocrinologicaly active due to interaction with estrogen receptors and due to modulation of several hormonogenic metabolic pathways. Genistein is well known inhibitor of tyrosine-protein kinases - the enzymes acting in post-receptor events of peptide hormone signaling. Dietary isoflavones have been reported protective against several types of neoplasias, cardiovascular diseaeses and menopausal symtoms. Enzyme-linked immunosorbent assays (ELISAs) were developed for determination of the most important isoflavones - i.e. genistein, daidzein and biochanin A in biological materials. The indirect competitive ELISA format uses polyclonal rabbit antibodies formed against conjugates of carboxymethyl isoflavones with bovine serum albumin

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Chemické listy

ISBN

0009-2770

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

310

Název nakladatele

Česká chemická společnost

Místo vydání

Praha

Místo konání akce

Devět Skal

Datum konání akce

9. 6. 2004

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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