RNA INTERFERENCE A PRAKTICKÉ ASPEKTY JEJÍHO VYUžITÍ

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F09%3A00022116" target="_blank" >RIV/60461373:22330/09:00022116 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

RNA INTERFERENCE A PRAKTICKÉ ASPEKTY JEJÍHO VYUžITÍ

Popis výsledku v původním jazyce

RNA interference (RNAi) is a natural mechanism that inhibits gene expression at the stage of translation or by blocking the transcription of specific genes. RNAi targets include RNA from viruses and transposons which could contribute to innate immune response. RNAi plays a key role in regulating genom development and its maintenance. Small interfering RNA (siRNA) and micro RNA (miRNA) are a key to the RNAi process. Their nucleotide sequences are complementary to the target mRNA strand. The selective effect of RNAi on gene expression makes it a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. RNAi may also be used for large-scale screenings that systematically silence expression of genes in the cell, which can help identify the components necessary for a particular cell process. To develop an effective gene-silencing procedure, several approaches to the long-term intr

Název v anglickém jazyce

RNA Interference and Practical Aspects of Its Application

Popis výsledku anglicky

RNA interference (RNAi) is a natural mechanism that inhibits gene expression at the stage of translation or by blocking the transcription of specific genes. RNAi targets include RNA from viruses and transposons which could contribute to innate immune response. RNAi plays a key role in regulating genom development and its maintenance. Small interfering RNA (siRNA) and micro RNA (miRNA) are a key to the RNAi process. Their nucleotide sequences are complementary to the target mRNA strand. The selective effect of RNAi on gene expression makes it a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. RNAi may also be used for large-scale screenings that systematically silence expression of genes in the cell, which can help identify the components necessary for a particular cell process. To develop an effective gene-silencing procedure, several approaches to the long-term intr

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA500110805" target="_blank" >IAA500110805: Analýza mechanizmů autokrinních účinků adipokinů na metabolizmus glukózy a lipidů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

103

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000265518100008

EID výsledku v databázi Scopus

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