Development of spray-dried chitosan microcarriers for nanoparticle delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F13%3A43895516" target="_blank" >RIV/60461373:22330/13:43895516 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/13:43895516

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.005" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.12.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.005" target="_blank" >10.1016/j.powtec.2012.12.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of spray-dried chitosan microcarriers for nanoparticle delivery

Popis výsledku v původním jazyce

The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism.

Název v anglickém jazyce

Development of spray-dried chitosan microcarriers for nanoparticle delivery

Popis výsledku anglicky

The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/MEB061108" target="_blank" >MEB061108: Vývoj antibakteriálních polymerů na chitosanové bázi pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

235

Číslo periodika v rámci svazku

February 2013

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

797-805

Kód UT WoS článku

000316039400098

EID výsledku v databázi Scopus

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