ENCAPSULATION OF LACCASE IN CHITOSAN MICRO-CARRIERS BY TWO-FLUID AND THREE-FLUID NOZZLE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893673" target="_blank" >RIV/60461373:22340/12:43893673 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

ENCAPSULATION OF LACCASE IN CHITOSAN MICRO-CARRIERS BY TWO-FLUID AND THREE-FLUID NOZZLE

Popis výsledku v původním jazyce

Chitosan is a biocompatible and biodegradable polymer suitable for the encapsulation of both small molecules and biomolecules. The simultaneous encapsulation of a precursor (substrate) and immobilization of catalyst (enzyme) in a core-shell chitosan particle makes it possible to deliver active molecules with a short half-life by forming them in-situ from stable precursors. This is desirable e.g. in the case of biocidal molecules or sensorially active substances. The first objective of our study is to investigate the effect of composition (in particular, the TPP/chitosan ratio) and cross-linking method (ex-situ vs. in-situ) on the properties of chitosan microspheres formed by spray drying. The particle size distribution, particle morphology, zeta potential and swelling behaviour have been systematically investigated. A novel cross-linking method, based on in-situ contact of TPP and chitosan solutions directly at the nozzle orifice (3-fluid nozzle), has been developed and compared with a

Název v anglickém jazyce

ENCAPSULATION OF LACCASE IN CHITOSAN MICRO-CARRIERS BY TWO-FLUID AND THREE-FLUID NOZZLE

Popis výsledku anglicky

Chitosan is a biocompatible and biodegradable polymer suitable for the encapsulation of both small molecules and biomolecules. The simultaneous encapsulation of a precursor (substrate) and immobilization of catalyst (enzyme) in a core-shell chitosan particle makes it possible to deliver active molecules with a short half-life by forming them in-situ from stable precursors. This is desirable e.g. in the case of biocidal molecules or sensorially active substances. The first objective of our study is to investigate the effect of composition (in particular, the TPP/chitosan ratio) and cross-linking method (ex-situ vs. in-situ) on the properties of chitosan microspheres formed by spray drying. The particle size distribution, particle morphology, zeta potential and swelling behaviour have been systematically investigated. A novel cross-linking method, based on in-situ contact of TPP and chitosan solutions directly at the nozzle orifice (3-fluid nozzle), has been developed and compared with a

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2012 AIChE Annual Meeting

ISBN

978-0-8169-1073-1

ISSN

—

e-ISSN

—

Počet stran výsledku

7

Strana od-do

"692d-1"-"1-692d-7"

Název nakladatele

American Institute of Chemical Engineers by Omnipress

Místo vydání

New York

Místo konání akce

Pittsburgh

Datum konání akce

28. 10. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—