Encapsulation of active substances in chitosan micro-carriers by spray drying

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Encapsulation of active substances in chitosan micro-carriers by spray drying

Popis výsledku v původním jazyce

The first objective of our study is to investigate the effect of composition (in particular, the TPP/chitosan ratio) and cross-linking method (ex-situ vs. in-situ) on the properties of chitosan microspheres formed by spray drying. The particle size distribution, particle morphology, zeta potential and swelling behaviour have been systematically investigated. A novel cross-linking method, based on in-situ contact of TPP and chitosan solutions directly at the nozzle orifice (3- fluid nozzle), has been developed and compared with a more conventional approach of spraydrying a pre-mixed TPP/chitosan colloid solution using a 2-fluid nozzle. The second objective is encapsulation of active substance in form of nanoparticles (silver) and enzyme (laccase). The nanoparticles chosen for the encapsulation and release from the crosslinked chitosan matrix were those of silver, due to their well-established antibacterial effect.

Název v anglickém jazyce

Encapsulation of active substances in chitosan micro-carriers by spray drying

Popis výsledku anglicky

The first objective of our study is to investigate the effect of composition (in particular, the TPP/chitosan ratio) and cross-linking method (ex-situ vs. in-situ) on the properties of chitosan microspheres formed by spray drying. The particle size distribution, particle morphology, zeta potential and swelling behaviour have been systematically investigated. A novel cross-linking method, based on in-situ contact of TPP and chitosan solutions directly at the nozzle orifice (3- fluid nozzle), has been developed and compared with a more conventional approach of spraydrying a pre-mixed TPP/chitosan colloid solution using a 2-fluid nozzle. The second objective is encapsulation of active substance in form of nanoparticles (silver) and enzyme (laccase). The nanoparticles chosen for the encapsulation and release from the crosslinked chitosan matrix were those of silver, due to their well-established antibacterial effect.

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

CHOBOTIX 2012

ISBN

978-80-7080-813-9

ISSN

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e-ISSN

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Počet stran výsledku

13

Strana od-do

75-87

Název nakladatele

ICT Press, VŠCHT Praha

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

10. 5. 2012

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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