Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43901833" target="_blank" >RIV/60461373:22330/16:43901833 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/16:70772 RIV/60460709:41340/16:70772

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bjp.2016.03.016" target="_blank" >http://dx.doi.org/10.1016/j.bjp.2016.03.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bjp.2016.03.016" target="_blank" >10.1016/j.bjp.2016.03.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Popis výsledku v původním jazyce

Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 +/- 51.4 mu g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 mu g/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 mu g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 mu g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

Název v anglickém jazyce

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Popis výsledku anglicky

Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 +/- 51.4 mu g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 mu g/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 mu g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 mu g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GM - Potravinářství

OECD FORD obor

—

Projekt

<a href="/cs/project/LD14070" target="_blank" >LD14070: Adhesivní vlastnosti probiotických kmenů k buňkám střevní mukozy</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Revista Brasileira de Farmacognosia

ISSN

0102-695X

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

BR - Brazilská federativní republika

Počet stran výsledku

10

Strana od-do

728-737

Kód UT WoS článku

000389621500011

EID výsledku v databázi Scopus

2-s2.0-85006263965