Impact of Air Pollution to Genome of Newborns
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43903021" target="_blank" >RIV/60461373:22330/16:43903021 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/16:00472879 RIV/60076658:12110/16:43891151
Výsledek na webu
<a href="http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf" target="_blank" >http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21101/cejph.a4536" target="_blank" >10.21101/cejph.a4536</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Impact of Air Pollution to Genome of Newborns
Popis výsledku v původním jazyce
The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.
Název v anglickém jazyce
Impact of Air Pollution to Genome of Newborns
Popis výsledku anglicky
The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
DN - Vliv životního prostředí na zdraví
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-13458S" target="_blank" >GA13-13458S: Dopady znečištění ovzduší na genom novorozenců</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Central European Journal of Public Health
ISSN
1210-7778
e-ISSN
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Svazek periodika
24
Číslo periodika v rámci svazku
December
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
5
Strana od-do
"S40"-"S44"
Kód UT WoS článku
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EID výsledku v databázi Scopus
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