Impact of Air Pollution to Genome of Newborns

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43903021" target="_blank" >RIV/60461373:22330/16:43903021 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/16:00472879 RIV/60076658:12110/16:43891151

Výsledek na webu

<a href="http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf" target="_blank" >http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a4536" target="_blank" >10.21101/cejph.a4536</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of Air Pollution to Genome of Newborns

Popis výsledku v původním jazyce

The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.

Název v anglickém jazyce

Impact of Air Pollution to Genome of Newborns

Popis výsledku anglicky

The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-13458S" target="_blank" >GA13-13458S: Dopady znečištění ovzduší na genom novorozenců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

"S40"-"S44"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—