Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory activity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F17%3A43914451" target="_blank" >RIV/60461373:22330/17:43914451 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.dl.begellhouse.com/journals/708ae68d64b17c52,305c54e9703680c8,1cb5fe9d1c31da44.html" target="_blank" >http://www.dl.begellhouse.com/journals/708ae68d64b17c52,305c54e9703680c8,1cb5fe9d1c31da44.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1615/IntJMedMushrooms.2017024413" target="_blank" >10.1615/IntJMedMushrooms.2017024413</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory activity
Popis výsledku v původním jazyce
Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly beta-glucans, mannogalactans, and glycogen (e.g., alpha-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more beta-(1 -> 3)-glucans than beta-(1 -> 3),(1 -> 6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
Název v anglickém jazyce
Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory activity
Popis výsledku anglicky
Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly beta-glucans, mannogalactans, and glycogen (e.g., alpha-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more beta-(1 -> 3)-glucans than beta-(1 -> 3),(1 -> 6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10612 - Mycology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Medicinal Mushrooms
ISSN
1521-9437
e-ISSN
—
Svazek periodika
19
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
SI - Slovinská republika
Počet stran výsledku
14
Strana od-do
879-892
Kód UT WoS článku
000417065300003
EID výsledku v databázi Scopus
2-s2.0-85037060097