Plasma lipidome differences in patients with and without significant carotid plaque

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F24%3A43929057" target="_blank" >RIV/60461373:22330/24:43929057 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/25:00563524 RIV/61383082:_____/24:00001434 RIV/00216208:11110/24:10480019 RIV/00216208:11120/24:43926990 RIV/00064173:_____/24:43926990

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1537189124001034?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1537189124001034?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vph.2024.107377" target="_blank" >10.1016/j.vph.2024.107377</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma lipidome differences in patients with and without significant carotid plaque

Popis výsledku v původním jazyce

Background: Atherosclerosis is a major cause of ischemic stroke, and early detection of advanced atherosclerosis in the carotid artery is important for reducing morbidity and mortality. What is even more important is not only detection of atherosclerosis but early determination whether the patients are at high risk of an event with adverse effects as the size of the plaque does not necessarily reflect its potential to trigger such events. Aim: We studied whether plasma lipidomics profile can be used as a diagnostic tool for stratification of stable or unstable plaques without the need of removing the carotid plaque. Methods: This study used liquid chromatography high-resolution tandem mass spectrometry lipidomics to characterize lipid profiles in patients&apos; plasma and found that patients with significant and complicated (vulnerable) atherosclerotic plaque had distinct lipid profiles compared to those with insignificant plaques. Results: The lipid classes that were most predictive of vulnerable plaque were lysophosphoethanolamines, fatty acyl esters of hydroxy fatty acids, free fatty acids, plasmalogens, and triacylglycerols. Most of these compounds were found decreased in plasma of patients with unstable plaques which enabled sufficient performance of a statistical model used for patient stratification. Conclusions: Plasma lipidomes measured by liquid chromatography-mass spectrometry show differences in patients with stable and unstable carotid plaques, therefore these compounds could potentially be used as biomarkers for unstable plaque in future clinical diagnosis.

Název v anglickém jazyce

Plasma lipidome differences in patients with and without significant carotid plaque

Popis výsledku anglicky

Background: Atherosclerosis is a major cause of ischemic stroke, and early detection of advanced atherosclerosis in the carotid artery is important for reducing morbidity and mortality. What is even more important is not only detection of atherosclerosis but early determination whether the patients are at high risk of an event with adverse effects as the size of the plaque does not necessarily reflect its potential to trigger such events. Aim: We studied whether plasma lipidomics profile can be used as a diagnostic tool for stratification of stable or unstable plaques without the need of removing the carotid plaque. Methods: This study used liquid chromatography high-resolution tandem mass spectrometry lipidomics to characterize lipid profiles in patients&apos; plasma and found that patients with significant and complicated (vulnerable) atherosclerotic plaque had distinct lipid profiles compared to those with insignificant plaques. Results: The lipid classes that were most predictive of vulnerable plaque were lysophosphoethanolamines, fatty acyl esters of hydroxy fatty acids, free fatty acids, plasmalogens, and triacylglycerols. Most of these compounds were found decreased in plasma of patients with unstable plaques which enabled sufficient performance of a statistical model used for patient stratification. Conclusions: Plasma lipidomes measured by liquid chromatography-mass spectrometry show differences in patients with stable and unstable carotid plaques, therefore these compounds could potentially be used as biomarkers for unstable plaque in future clinical diagnosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

VASCULAR PHARMACOLOGY

ISSN

1537-1891

e-ISSN

—

Svazek periodika

155

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

001239652900001

EID výsledku v databázi Scopus

2-s2.0-85192176054