Bile pigment complexes with cyclodextrins: electronic and vibrational circular dichroism study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F07%3A00018103" target="_blank" >RIV/60461373:22340/07:00018103 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bile pigment complexes with cyclodextrins: electronic and vibrational circular dichroism study

Popis výsledku v původním jazyce

Chiral recognition of bilirubin IX-a, biliverdin IX-a, and bilirubin ditaurate dianions by cyclodextrins was studied using a combination of vibrational and electronic circular dichroism. Biliverdin forms inclusion complexes with b-cyclodextrin and b-methylcyclodextrin. Bilirubin bonds to both cyclodextrins by means of hydrogen bonds and only shallow inclusions that are restricted by the presence of COO- in the pigment structure. Bilirubin ditaurate complexes are realized by a weak inclusion of the wholemolecule, or some part of it, into the cyclodextrin cavity and stabilization of the conformation by hydrogen bonds. Bilirubin and bilirubin ditaurate can be recognized by cyclodextrin and methylcyclodextrin in the form of opposite conformers. Spectroscopic characteristics of the different conformations of the bile pigments were obtained for the first time by vibrational circular dichroism techniques.

Název v anglickém jazyce

Bile pigment complexes with cyclodextrins: electronic and vibrational circular dichroism study

Popis výsledku anglicky

Chiral recognition of bilirubin IX-a, biliverdin IX-a, and bilirubin ditaurate dianions by cyclodextrins was studied using a combination of vibrational and electronic circular dichroism. Biliverdin forms inclusion complexes with b-cyclodextrin and b-methylcyclodextrin. Bilirubin bonds to both cyclodextrins by means of hydrogen bonds and only shallow inclusions that are restricted by the presence of COO- in the pigment structure. Bilirubin ditaurate complexes are realized by a weak inclusion of the wholemolecule, or some part of it, into the cyclodextrin cavity and stabilization of the conformation by hydrogen bonds. Bilirubin and bilirubin ditaurate can be recognized by cyclodextrin and methylcyclodextrin in the form of opposite conformers. Spectroscopic characteristics of the different conformations of the bile pigments were obtained for the first time by vibrational circular dichroism techniques.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tetrahedron Asymmetry

ISSN

0957-4166

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

8

Strana od-do

2061-2068

Kód UT WoS článku

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EID výsledku v databázi Scopus

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