Supramolecular arrangement of guanosine/5''-guanosine monophosphate binary mixtures studied by methods of circular dichroism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893262" target="_blank" >RIV/60461373:22340/12:43893262 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/chir.22045" target="_blank" >http://dx.doi.org/10.1002/chir.22045</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chir.22045" target="_blank" >10.1002/chir.22045</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Supramolecular arrangement of guanosine/5''-guanosine monophosphate binary mixtures studied by methods of circular dichroism

Popis výsledku v původním jazyce

Self-assembly of molecules is one of the fundamental processes in biology and in supramolecular chemistry. Guanosine (Guo) and its derivatives are among the widely studied molecules because of self-assembly abilities. Their tetrameric associates are thenature of telomeric DNA, and furthermore they are fundamental building blocks of supramolecular reversible gels, which may arise in certain physical and chemical conditions. Although poorly soluble in water, Guo forms interesting structures with guanosine 5'-monophosphate salt (GMP) in the TRIS buffer. We used electronic circular dichroism and vibrational circular dichroism to describe the thermal response of gels formed by the Guo/GMP binary mixture. Using these complementary techniques suitable to study conformational changes of chiral compounds, we obtained information about the involvement of functional groups and weak interactions in the guanosine quartet (G4) and stacked G4 structures.

Název v anglickém jazyce

Supramolecular arrangement of guanosine/5''-guanosine monophosphate binary mixtures studied by methods of circular dichroism

Popis výsledku anglicky

Self-assembly of molecules is one of the fundamental processes in biology and in supramolecular chemistry. Guanosine (Guo) and its derivatives are among the widely studied molecules because of self-assembly abilities. Their tetrameric associates are thenature of telomeric DNA, and furthermore they are fundamental building blocks of supramolecular reversible gels, which may arise in certain physical and chemical conditions. Although poorly soluble in water, Guo forms interesting structures with guanosine 5'-monophosphate salt (GMP) in the TRIS buffer. We used electronic circular dichroism and vibrational circular dichroism to describe the thermal response of gels formed by the Guo/GMP binary mixture. Using these complementary techniques suitable to study conformational changes of chiral compounds, we obtained information about the involvement of functional groups and weak interactions in the guanosine quartet (G4) and stacked G4 structures.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chirality

ISSN

0899-0042

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

432-438

Kód UT WoS článku

000303237200012

EID výsledku v databázi Scopus

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