Guanosine assemblies: newly used matrices for chiroptical studies on biliverdin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F14%3A43895203" target="_blank" >RIV/60461373:22340/14:43895203 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.tandfonline.com/doi/pdf/10.1080/10610278.2013.814774" target="_blank" >http://www.tandfonline.com/doi/pdf/10.1080/10610278.2013.814774</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10610278.2013.814774" target="_blank" >10.1080/10610278.2013.814774</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Guanosine assemblies: newly used matrices for chiroptical studies on biliverdin

Popis výsledku v původním jazyce

Guanine derivatives and biliverdin (BV) are biologically important units. As BV racemises in solution, we utilised various guanine assemblies as suitable sensitive matrices for the enantioselective recognition of BV in circular dichroism (CD) studies. Using electronic CD, we separately detected the interacting P form of BV (visible) and its effect on guanosine (Guo) assemblies (UV). The interaction of the P form was con?rmed by vibrational CD even though the signals of Guo and BV overlapped. BV preferred the monomers and vertical stacks ((M)n) of guanosine 5'-monophosphate (GMP) as interacting partners. BV?GMP interaction was also observed in the case of vertically assembled GMP quartets ((G4)n), but this interaction was shown to be destructive for (G4)n. To stabilise (G4)n assemblies more intensively and to protect them against disruption by BV, we applied Guo. BV reorganised the Guo/GMP supramolecular structure although it had demonstrated high stability in our previous study.

Název v anglickém jazyce

Guanosine assemblies: newly used matrices for chiroptical studies on biliverdin

Popis výsledku anglicky

Guanine derivatives and biliverdin (BV) are biologically important units. As BV racemises in solution, we utilised various guanine assemblies as suitable sensitive matrices for the enantioselective recognition of BV in circular dichroism (CD) studies. Using electronic CD, we separately detected the interacting P form of BV (visible) and its effect on guanosine (Guo) assemblies (UV). The interaction of the P form was con?rmed by vibrational CD even though the signals of Guo and BV overlapped. BV preferred the monomers and vertical stacks ((M)n) of guanosine 5'-monophosphate (GMP) as interacting partners. BV?GMP interaction was also observed in the case of vertically assembled GMP quartets ((G4)n), but this interaction was shown to be destructive for (G4)n. To stabilise (G4)n assemblies more intensively and to protect them against disruption by BV, we applied Guo. BV reorganised the Guo/GMP supramolecular structure although it had demonstrated high stability in our previous study.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Supramolecular Chemistry

ISSN

1061-0278

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

7-14

Kód UT WoS článku

000328599500003

EID výsledku v databázi Scopus

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