Mathematical modelling of Wurster fluid bed coating

Kód výsledku v IS VaVaI

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RIV/60461373:22340/19:43919989

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mathematical modelling of Wurster fluid bed coating

Popis výsledku v původním jazyce

Wurster fluid bed coating is an effective way of manufacturing the layers used to create drug delivery systems, but it requires very precise control. On an industrial scale, the optimization of Wurster coating process parameters can be demanding because it necessitates many time-consuming pilot-scale experiments, the scope of which is limited by the cost of APIs. In this presentation we summarize results of our thermodynamic model and show its applicability as an analytical and predictive tool for drug production optimization. In the second part, we discuss possibility to extend the model with results extracted from CFD-DEM simulations.

Název v anglickém jazyce

Mathematical modelling of Wurster fluid bed coating

Popis výsledku anglicky

Wurster fluid bed coating is an effective way of manufacturing the layers used to create drug delivery systems, but it requires very precise control. On an industrial scale, the optimization of Wurster coating process parameters can be demanding because it necessitates many time-consuming pilot-scale experiments, the scope of which is limited by the cost of APIs. In this presentation we summarize results of our thermodynamic model and show its applicability as an analytical and predictive tool for drug production optimization. In the second part, we discuss possibility to extend the model with results extracted from CFD-DEM simulations.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů