New designed special cells for Raman mapping of the disintegration process of pharmaceutical tablets
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43917718" target="_blank" >RIV/60461373:22340/19:43917718 - isvavai.cz</a>
Výsledek na webu
<a href="https://reader.elsevier.com/reader/sd/pii/S0731708518324865?token=78621B7972431DF4BA9C2624578FCBA1FEFFB4EE5E06234468A2D9A325D17DB24825C10817D9398704C0281BE9E43A86" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0731708518324865?token=78621B7972431DF4BA9C2624578FCBA1FEFFB4EE5E06234468A2D9A325D17DB24825C10817D9398704C0281BE9E43A86</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2019.02.019" target="_blank" >10.1016/j.jpba.2019.02.019</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
New designed special cells for Raman mapping of the disintegration process of pharmaceutical tablets
Popis výsledku v původním jazyce
The goal of this study was the methodological development of Raman microscopy application for advanced and reliable monitoring of pharmaceutical tablets disintegration in aqueous media. First step of the development involved new design and testing of static, flow cell and tablet holders. On-line Raman mapping method enables observation of the tested tablet interphase changes, particularly the changes of tablet composition during interaction of the solid-state drug form with disintegration medium. Furthermore, the quantitative information of tablet components (% w/w) from Raman maps was calculated. Second part of this study performs off-line Raman mapping, which was focused on the mapping of disintegrated tablet residua. Time-dependent Raman chemical maps provide an understanding of the role of several synergic processes, e.g. solvation, solvent penetration, both active pharmaceutical ingredient and excipient dissolution etc., which occur simultaneously on the surface of dissolving tablet. Raman data of disintegration process were evaluated by a chemometric method – Principal Component Analysis (PCA).
Název v anglickém jazyce
New designed special cells for Raman mapping of the disintegration process of pharmaceutical tablets
Popis výsledku anglicky
The goal of this study was the methodological development of Raman microscopy application for advanced and reliable monitoring of pharmaceutical tablets disintegration in aqueous media. First step of the development involved new design and testing of static, flow cell and tablet holders. On-line Raman mapping method enables observation of the tested tablet interphase changes, particularly the changes of tablet composition during interaction of the solid-state drug form with disintegration medium. Furthermore, the quantitative information of tablet components (% w/w) from Raman maps was calculated. Second part of this study performs off-line Raman mapping, which was focused on the mapping of disintegrated tablet residua. Time-dependent Raman chemical maps provide an understanding of the role of several synergic processes, e.g. solvation, solvent penetration, both active pharmaceutical ingredient and excipient dissolution etc., which occur simultaneously on the surface of dissolving tablet. Raman data of disintegration process were evaluated by a chemometric method – Principal Component Analysis (PCA).
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Pharmaceutical and Biomedical Analysis
ISSN
0731-7085
e-ISSN
—
Svazek periodika
168
Číslo periodika v rámci svazku
10 May 2019
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
11
Strana od-do
113-123
Kód UT WoS článku
000463305700013
EID výsledku v databázi Scopus
2-s2.0-85061808706